53787
卡拉洛尔
analytical standard
别名:
1-(咔唑-4-氧基)-3-(异丙基氨基)-2-丙醇, 4-(2-羟基-3-异丙胺基-丙氧基)咔唑
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关于此项目
经验公式（希尔记法）:
C18H22N2O2
化学文摘社编号:
分子量:
298.38
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
260-945-1
Beilstein/REAXYS Number:
3620576
MDL number:
产品名称
卡拉洛尔, analytical standard
InChI key
BQXQGZPYHWWCEB-UHFFFAOYSA-N
InChI
1S/C18H22N2O2/c1-12(2)19-10-13(21)11-22-17-9-5-8-16-18(17)14-6-3-4-7-15(14)20-16/h3-9,12-13,19-21H,10-11H2,1-2H3
SMILES string
CC(C)NCC(O)COc1cccc2[nH]c3ccccc3c12
grade
analytical standard
assay
≥98.5% (HPLC)
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
solid phase extraction (SPE): suitable
mp
133-137 °C
application(s)
forensics and toxicology
pharmaceutical (small molecule)
veterinary
format
neat
storage temp.
2-8°C
Quality Level
General description
Supelco MIP SPE 滤筒标准品。更多信息，请参阅 Supelco 文献 T407075、T706030 和 T706025。
Application
Carazolol may be used as a reference standard for the determination of the analyte:
- In swine kidney by high-performance liquid chromatography with ultraviolet and fluorescence detection.
- In animal tissues by high-performance liquid chromatography with electrochemical detection.
Commission Regulation (EU) No 37/2010 of 22 December 2009 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Karin A Stephenson et al.
Journal of medicinal chemistry, 51(16), 5093-5100 (2008-07-29)
An efficient and general method has been developed for fluorine-18 labeling of beta-blockers that possess the propanolamine moiety. A new synthetically versatile intermediate, 3-(1-(benzyloxy)propan-2-yl)-2-oxooxazolidin-5-yl)methyl 4-methylbenzenesulfonate (13), was prepared and can be conjugated to any phenoxy core. To demonstrate the synthetic
Determination of tranquilisers and carazolol residues in animal tissue using high-performance liquid chromatography with electrochemical detection.
Rose MD and Shearer G
Journal of Chromatography A, 624(1-2), 471- 477 (1992)
Determination of residues of carazolol and a number of tranquilizers in swine kidney by high-performance liquid chromatography with ultraviolet and fluorescence detection.
Keukens HJ and Aerts MML
Journal of Chromatography A, 464, 149- 161 (1991)
Stefano Costanzi
Journal of medicinal chemistry, 51(10), 2907-2914 (2008-04-30)
The publication of the crystal structure of the beta2-adrenergic receptor (beta2-AR) proved that G protein-coupled receptors (GPCRs) share a structurally conserved rhodopsin-like 7TM core. Here, to probe to which extent realistic GPCR structures can be recreated through modeling, carazolol was
Chris de Graaf et al.
Journal of medicinal chemistry, 51(16), 4978-4985 (2008-08-06)
The recently solved high-resolution X-ray structure of the beta2 adrenergic receptor has been challenged for its ability to discriminate inverse agonists/antagonists from partial/full agonists. Whereas the X-ray structure of the ground state receptor was unsuitable to distinguish true ligands with
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