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线性分子式:
(CF3)2CHOH
化学文摘社编号:
分子量:
168.04
UNSPSC Code:
12352104
NACRES:
NA.05
PubChem Substance ID:
EC Number:
213-059-4
Beilstein/REAXYS Number:
1841007
MDL number:
产品名称
1,1,1,3,3,3-六氟-2-丙醇, derivatization grade (GC derivatization), LiChropur™, ≥99.8%
InChI key
BYEAHWXPCBROCE-UHFFFAOYSA-N
InChI
1S/C3H2F6O/c4-2(5,6)1(10)3(7,8)9/h1,10H
SMILES string
OC(C(F)(F)F)C(F)(F)F
grade
derivatization grade (GC derivatization)
assay
≥99.8% (GC)
≥99.8%
quality
LiChropur™
reaction suitability
reagent type: derivatization reagent
reaction type: Acylations
reagent type: derivatization reagent
reaction type: Esterifications
technique(s)
gas chromatography (GC): suitable
refractive index
n20/D 1.275 (lit.)
bp
59 °C (lit.)
mp
−4 °C (lit.)
density
1.596 g/mL at 25 °C (lit.)
Quality Level
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Other Notes
六氟异丙基酯、N-五氟丙基和三氟乙酰基的衍生化试剂。
1,1,1,3,3,3-六氟-2-丙醇中的尺寸排阻色谱
Legal Information
LiChropur is a trademark of Merck KGaA, Darmstadt, Germany
Application
适于衍生化谷氨酸、高香草酸、异香草醛和二羟基苯乙酸和Υ-氨基丁酸。
General description
六氟异丙醇(HFP)通常用于天然状态蛋白质变性,还能稳定未折叠多肽和蛋白质,如ß-乳球蛋白和蜂毒素的a-螺旋构型。
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Repr. 2 - Skin Corr. 1A - STOT RE 2
存储类别
8A - Combustible corrosive hazardous materials
wgk
WGK 2
flash_point_f
No data available
flash_point_c
No data available
ppe
Faceshields, Gloves, Goggles
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Journal of chromatography. A, 964(1-2), 169-178 (2002-08-30)
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Journal of enzyme inhibition and medicinal chemistry, 33(1), 290-302 (2017-12-28)
Small molecule cholinesterases inhibitor (ChEI) provides an effective therapeutic strategy to treat Alzheimer's disease (AD). Currently, the discovery of new ChEI with multi-target effect is still of great importance. Herein, we report the synthesis, structure-activity relationship study and biological evaluation
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