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About This Item
线性分子式:
HCHO
CAS号:
分子量:
30.03
Beilstein:
1209228
MDL编号:
UNSPSC代码:
12352114
PubChem化学物质编号:
NACRES:
NA.25
Agency
USP/NF
tested according to Ph. Eur.
质量水平
蒸汽密度
1.03 (vs air)
蒸汽压
52 mmHg ( 37 °C)
形式
liquid
自燃温度
572 °F
包含
9.0-15.0 % (v/v) methanol as stabilizer
浓度
25-50%
溶解性
water: soluble
密度
1.09 g/mL at 25 °C (lit.)
适用性
suitable for manufacturing use (Laboratory chemicals)
SMILES字符串
[H]C([H])=O
InChI
1S/CH2O/c1-2/h1H2
InChI key
WSFSSNUMVMOOMR-UHFFFAOYSA-N
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应用
在流式细胞术中，甲醛溶液已被用于固定标记的细胞。
生化/生理作用
甲醛是最简单的醛，其可使RNA的双螺旋区域变性并将多核苷酸转化为无规卷曲。 它是一种遗传毒性物质，可显著诱导DNA-蛋白质交联（DPC）、姐妹染色单体交换、微核形成并导致细胞毒性。 它还在大鼠的鼻上皮中诱导肿瘤并且被认为是人类致癌物。
注意
储存时可能变混浊
警示用语：
Danger
危险分类
Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Carc. 1B - Eye Dam. 1 - Flam. Liq. 3 - Muta. 2 - Skin Corr. 1B - Skin Sens. 1 - STOT SE 1 - STOT SE 3
靶器官
Eyes,Central nervous system, Respiratory system
WGK
WGK 3
闪点(°F)
133.0 °F
闪点(°C)
56.11 °C
个人防护装备
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
法规信息
危险化学品
O Merk et al.
Environmental and molecular mutagenesis, 32(3), 260-268 (1998-11-14)
Formaldehyde (FA) is a genotoxic substance, induces tumors in the nasal epithelium of rats, and is suspected to be a human carcinogen. As a primary DNA lesion, FA induces DNA-protein crosslinks (DPC) and the formation of DPC has been used
J L Wilson et al.
Journal of immunology (Baltimore, Md. : 1950), 163(12), 6365-6370 (1999-12-10)
NK cells have the capacity to spontaneously kill tumor cell lines, in particular cell lines of hemopoietic origin. In contrast, they do not generally kill nontransformed autologous cells. However, here we demonstrate that short-term activated polyclonal human NK cells, as
Dependence of the sedimentation coefficient on molecular weight of RNA after reaction with formaldehyde.
H Boedtker
Journal of molecular biology, 35(1), 61-70 (1968-07-14)
Cindy S Ma et al.
The Journal of experimental medicine, 205(7), 1551-1557 (2008-07-02)
Hyper-immunoglobulin E syndrome (HIES) is a primary immune deficiency characterized by abnormal and devastating susceptibility to a narrow spectrum of infections, most commonly Staphylococcus aureus and Candida albicans. Recent investigations have identified mutations in STAT3 in the majority of HIES
Stephanie Belloc et al.
Fertility and sterility, 101(6), 1588-1593 (2014-04-03)
To evaluate sperm DNA fragmentation in normozoospermic male partners of couples undergoing infertility evaluation. Retrospective cohort study. Clinical andrology laboratory. A total of 1,974 consecutive normozoospermic men selected from a larger cohort of 4,345 consecutive, nonazoospermic men presenting for infertility
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