46542
α-雌二醇
VETRANAL®, analytical standard
别名:
1,3,5(10)雌甾三烯-3,17α-二醇, 3,17α-二羟基-1,3,5(10)-雌三烯, 雌二醇
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关于此项目
经验公式（希尔记法）:
C18H24O2
化学文摘社编号:
分子量:
272.38
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
200-354-8
MDL number:
grade
analytical standard
Quality Level
product line
VETRANAL®
optical activity
[α]/D 52.0 to 56.0°, c = 1 in ethanol
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
impurities
≤2.0% water
application(s)
pharmaceutical (small molecule)
format
neat
SMILES string
[H][C@]12CC[C@]3(C)[C@H](O)CC[C@@]3([H])[C@]1([H])CCc4cc(O)ccc24
InChI
1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17-,18+/m1/s1
InChI key
VOXZDWNPVJITMN-SFFUCWETSA-N
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
雌二醇（称为 α 雌二醇或 17 α 雌二醇）是组织培养中人乳腺癌细胞中的一种具有生物活性的雌激素。17-雌二醇及其选择性受体 ER-X 不属于经典激素/受体内分泌系统，而是属于在发育中和成人大脑中具有重要的自分泌/旁分泌功能的系统。17-雌二醇可能对更年期的激素替代策略以及治疗阿尔茨海默病和缺血性中风等神经退行性疾病具有重大意义。
Legal Information
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
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signalword
Danger
Hazard Classifications
Aquatic Chronic 1 - Carc. 2 - Lact. - Muta. 2 - Repr. 1A
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
C Y Cheng et al.
Fertility and sterility, 32(5), 566-570 (1979-11-01)
In modified Tyrode's solution, 17 beta-estradiol at concentrations between 0.1 microgram/ml and 320 nmoles/ml was effective in increasing human spermatozoal forward migration. 17 alpha-Estradiol, although structurally similar to 17 beta-estradiol, had no effect on human spermatozoal motility. DL-Norgestrel at concentrations
J Pitt et al.
Journal of inherited metabolic disease, 25(2), 83-88 (2002-07-18)
Three patients with ketosis had increased excretion of 3-hydroxyglutarate (21.8-37.9 micromol/mmol creatinine; controls 2.3 +/- 1.6), an indicator of glutaryl-CoA dehydrogenase deficiency (GDHD), which normalized when the patients were nonketotic. Clinical assessment of all three patients and enzyme studies in
Cristian G Bologa et al.
Nature chemical biology, 2(4), 207-212 (2006-03-08)
Estrogen is a hormone critical in the development, normal physiology and pathophysiology of numerous human tissues. The effects of estrogen have traditionally been solely ascribed to estrogen receptor alpha (ERalpha) and more recently ERbeta, members of the soluble, nuclear ligand-activated
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 46542-100MG | 04061832357119 |