等级
analytical standard
质量水平
描述
mixture of stereo isomers
产品线
PESTANAL®
检测方案
≥95% (HPLC)
保质期
limited shelf life, expiry date on the label
技术
HPLC: suitable
gas chromatography (GC): suitable
溶解性
H2O: slightly soluble
抗生素抗菌谱
fungi
应用
agriculture
cleaning products
cosmetics
environmental
food and beverages
personal care
格式
neat
作用机制
protein synthesis | interferes
储存温度
−20°C
SMILES字符串
[H][C@]1(C[C@@H](C)C[C@H](C)C1=O)[C@H](O)CC2CC(=O)NC(=O)C2
InChI
1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
InChI key
YPHMISFOHDHNIV-FSZOTQKASA-N
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一般描述
环己酰亚胺是一种具有显著抗真菌特性的抗生素。它由产链霉素的灰色链霉菌菌株产生，并通过抑制蛋白质合成发挥作用。它的主要生物学活性是真核生物中的翻译抑制，从而导致细胞生长停滞和细胞死亡。它被用作杀菌剂。
根据废除91/414指令的第1107/2009号法规（EC），环己酰亚胺未被批准在欧盟使用。
根据废除91/414指令的第1107/2009号法规（EC），环己酰亚胺未被批准在欧盟使用。
应用
环己酰亚胺可能有以下用途：
- 评估环己酰亚胺作为 Optisol GS 补充剂的抗真菌疗效和安全性
- 研究环己酰亚胺对切叶蚁工蚁的影响
- 研究链霉素、环己酰亚胺、菌唑、克菌丹、呋喃丹、乐果和五氯硝基苯对土壤微生物的影响
- 半干旱草地一氧化二氮生产的真菌控制研究
- 链霉素和环己酰亚胺在土壤中的活性及其降解研究
生化/生理作用
作用机制：真核生物中的翻译抑制导致细胞生长停滞和细胞死亡。CHX被广泛用于抗CHX的酵母和真菌菌株的选择、蛋白质合成的受控抑制以检测短寿命蛋白质和蛋白质表达的超诱导作用、以及诱导凋亡或促进通过死亡受体诱导的凋亡。
活性谱：具有抑制酵母和真菌如念珠菌、曲霉、酵母菌和青霉的活性
活性谱：具有抑制酵母和真菌如念珠菌、曲霉、酵母菌和青霉的活性
法律信息
PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险分类
Acute Tox. 2 Oral - Aquatic Chronic 2 - Muta. 2 - Repr. 1B
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
监管及禁止进口产品
Matthias Rottmann et al.
Science (New York, N.Y.), 329(5996), 1175-1180 (2010-09-04)
Recent reports of increased tolerance to artemisinin derivatives--the most recently adopted class of antimalarials--have prompted a need for new treatments. The spirotetrahydro-beta-carbolines, or spiroindolones, are potent drugs that kill the blood stages of Plasmodium falciparum and Plasmodium vivax clinical isolates
Marie Barberon et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(22), 8293-8298 (2014-05-21)
In plants, the controlled absorption of soil nutrients by root epidermal cells is critical for growth and development. IRON-REGULATED TRANSPORTER 1 (IRT1) is the main root transporter taking up iron from the soil and is also the main entry route
Minako Kaneda et al.
Plant physiology, 147(4), 1750-1760 (2008-06-14)
Secondary xylem (wood) formation in gymnosperms requires that the tracheid protoplasts first build an elaborate secondary cell wall from an array of polysaccharides and then reinforce it with lignin, an amorphous, three-dimensional product of the random radical coupling of monolignols.
Roxane Simeone et al.
PLoS pathogens, 8(2), e1002507-e1002507 (2012-02-10)
Survival within macrophages is a central feature of Mycobacterium tuberculosis pathogenesis. Despite significant advances in identifying new immunological parameters associated with mycobacterial disease, some basic questions on the intracellular fate of the causative agent of human tuberculosis in antigen-presenting cells
Anna Duarri et al.
Annals of neurology, 72(6), 870-880 (2013-01-03)
To identify the causative gene for the neurodegenerative disorder spinocerebellar ataxia type 19 (SCA19) located on chromosomal region 1p21-q21. Exome sequencing was used to identify the causal mutation in a large SCA19 family. We then screened 230 ataxia families for
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