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Merck
CN
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安全信息

45661

Supelco

番木鳖碱

PESTANAL®, analytical standard

别名:

(-)-番木鳖碱

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About This Item

经验公式（希尔记法）:
C21H22N2O2
CAS号:
57-24-9
分子量:
334.41
Beilstein:
52979
EC 号:
200-319-7
MDL编号:
MFCD00005941
UNSPSC代码:
41116107
PubChem化学物质编号:
329756875

等级

analytical standard

质量水平

100

产品线

PESTANAL®

保质期

limited shelf life, expiry date on the label

技术

HPLC: suitable
gas chromatography (GC): suitable

mp

284-286 °C (lit.)

应用

agriculture
cleaning products
cosmetics
environmental
food and beverages
forensics and toxicology
personal care
pharmaceutical (small molecule)

包装形式

neat

SMILES字符串

[H][C@@]12CC(=O)N3c4ccccc4[C@]56CC[N@H]7CC(=CCO1)[C@]([H])(C[C@@H]57)[C@]2([H])[C@]36[H]

InChI

1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1

InChI key

QMGVPVSNSZLJIA-FVWCLLPLSA-N

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一般描述

Strychnine is an alkaloid, available as a bioactive component in Semen Strychni, exhibiting analgesic, anti-inflammatory and anti-tumor effects. It is widely used in neurological research, treatment of genetic disorder nonketotic hyperglycinemia, treatment of stomach ailments, etc.

应用

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Strychnine may be used as an analytical reference standard for the quantification of the analyte in biological samples using liquid chromatography coupled to electrospray ionization mass spectrometry.

生化/生理作用

惊厥剂；与 NMDA 受体无关的甘氨酸受体拮抗剂。

法律信息

PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

象形图

Skull and crossbonesEnvironment
GHS06,GHS09

警示用语：

Danger

危险声明

H300 + H310,H410

危险分类

Acute Tox. 1 Dermal - Acute Tox. 1 Oral - Aquatic Acute 1 - Aquatic Chronic 1

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 2

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCBW8759

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Determination of strychnine and brucine in rat plasma using liquid chromatography electrospray ionization mass spectrometry
Xu Y, et al.
Journal of Pharmaceutical and Biomedical Analysis, 49(2), 487-491 (2009)
Application of solid phase microextraction to the determination of strychnine in blood
Borroso.M, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 816(1-2), 29-34 (2005)
The 100 Most Important Chemical Compounds: A Reference Guide (2005)
Edna Brustein et al.
Developmental neurobiology, 73(2), 168-175 (2012-08-14)
Glycine and GABA are depolarizing during early development, but the purpose of this paradoxical chloride-mediated depolarization remains unclear, especially at early stages. It was previously reported that suppressing glycine signaling from the beginning of development in zebrafish embryos caused an
Yan Lu et al.
The Journal of clinical investigation, 123(9), 4050-4062 (2013-08-28)
Neuropathic pain is characterized by mechanical allodynia induced by low-threshold myelinated Aβ-fiber activation. The original gate theory of pain proposes that inhibitory interneurons in the lamina II of the spinal dorsal horn (DH) act as "gate control" units for preventing
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