44925
DL-同型半胱氨酸
analytical standard
别名:
2-氨基-4-巯基丁酸
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关于此项目
线性分子式:
HSCH2CH2CH(NH2)COOH
化学文摘社编号:
分子量:
135.18
UNSPSC Code:
85151701
NACRES:
NA.24
PubChem Substance ID:
EC Number:
207-222-9
Beilstein/REAXYS Number:
1721683
MDL number:
InChI key
FFFHZYDWPBMWHY-UHFFFAOYSA-N
InChI
1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)
SMILES string
NC(CCS)C(O)=O
grade
analytical standard
assay
≥95% (T)
optical activity
[α]/D 0±1°, c = 1 in H2O
shelf life
limited shelf life, expiry date on the label
analyte chemical class(es)
amino acids, peptides, proteins
technique(s)
HPLC: suitable
color
white to off-white
mp
232-233 °C (lit.)
application(s)
food and beverages
format
neat
storage temp.
−20°C
Quality Level
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Application
同型半胱氨酸可用作分析参考标准品，通过不同色谱技术，定量生物样品中的同型半胱胺酸 。
有关合适仪器技术的更多信息，请参考产品的分析证书。如需进一步支持，请联系技术服务。
Biochem/physiol Actions
血浆同型半胱氨酸水平升高是冠心病和癌变的危险因素；可能是肿瘤细胞生长的标志物。
Analysis Note
鉴别 (LS-MS)：鉴别符合规定
Disclaimer
氩气下储存
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Joshua A Dubland et al.
Journal of mass spectrometry and advances in the clinical lab, 20, 1-10 (2021-11-26)
Inborn errors of propionate, cobalamin and methionine metabolism are targets for Newborn Screening (NBS) in most programs world-wide, and are primarily screened by analyzing for propionyl carnitine (C3) and methionine in dried blood spot (DBS) cards using tandem mass spectrometry
Rapid measurement of total plasma homocysteine by HPLC
Frick B, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 331(1-2), 19-23 (2003)
Ghulam Mohammad et al.
International journal of molecular sciences, 21(5) (2020-03-11)
High homocysteine is routinely observed in diabetic patients, and this non-protein amino acid is considered as an independent risk factor for diabetic retinopathy. Homocysteine biosynthesis from methionine forms S-adenosyl methionine (SAM), which is a major methyl donor critical in DNA
Pre-column derivatization high-performance liquid chromatographic method for determination of cysteine, cysteinyl-glycine, homocysteine and glutathione in plasma and cell extracts
Katrusiak.EA, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 758(2), 207-212 (2001)
Silvia Hoirisch-Clapauch et al.
Schizophrenia research, 159(1), 118-123 (2014-09-11)
Clot buster tissue plasminogen activator (tPA) and its end-product plasmin play a well-defined role in neurochemistry. They mediate a number of events that culminate in tolerance against excitotoxicity, hippocampal neurogenesis, synaptic remodeling, neuronal plasticity, cognitive and emotional processing. Abnormalities in
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