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Merck
CN

44925

Supelco

DL-同型半胱氨酸

analytical standard

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别名:
2-氨基-4-巯基丁酸
线性分子式:
HSCH2CH2CH(NH2)COOH
CAS号:
分子量:
135.18
Beilstein:
1721683
EC 号:
MDL编号:
UNSPSC代码:
85151701
PubChem化学物质编号:
NACRES:
NA.24

等级

analytical standard

质量水平

检测方案

≥95% (T)

旋光性

[α]/D 0±1°, c = 1 in H2O

保质期

limited shelf life, expiry date on the label

分析物化学类别

amino acids, peptides, proteins

技术

HPLC: suitable

颜色

white to off-white

mp

232-233 °C (lit.)

应用

food and beverages

格式

neat

储存温度

−20°C

SMILES字符串

NC(CCS)C(O)=O

InChI

1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)

InChI key

FFFHZYDWPBMWHY-UHFFFAOYSA-N

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应用

同型半胱氨酸可用作分析参考标准品,通过不同色谱技术,定量生物样品中的同型半胱胺酸
有关合适仪器技术的更多信息,请参考产品的分析证书。如需进一步支持,请联系技术服务。

生化/生理作用

血浆同型半胱氨酸水平升高是冠心病和癌变的危险因素;可能是肿瘤细胞生长的标志物。

注意

氩气下储存

分析说明

鉴别 (LS-MS):鉴别符合规定

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


分析证书(COA)

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Rapid measurement of total plasma homocysteine by HPLC
Frick B, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 331(1-2), 19-23 (2003)
Joshua A Dubland et al.
Journal of mass spectrometry and advances in the clinical lab, 20, 1-10 (2021-11-26)
Inborn errors of propionate, cobalamin and methionine metabolism are targets for Newborn Screening (NBS) in most programs world-wide, and are primarily screened by analyzing for propionyl carnitine (C3) and methionine in dried blood spot (DBS) cards using tandem mass spectrometry
Pre-column derivatization high-performance liquid chromatographic method for determination of cysteine, cysteinyl-glycine, homocysteine and glutathione in plasma and cell extracts
Katrusiak.EA, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 758(2), 207-212 (2001)
Ghulam Mohammad et al.
International journal of molecular sciences, 21(5) (2020-03-11)
High homocysteine is routinely observed in diabetic patients, and this non-protein amino acid is considered as an independent risk factor for diabetic retinopathy. Homocysteine biosynthesis from methionine forms S-adenosyl methionine (SAM), which is a major methyl donor critical in DNA
Silvia Hoirisch-Clapauch et al.
Schizophrenia research, 159(1), 118-123 (2014-09-11)
Clot buster tissue plasminogen activator (tPA) and its end-product plasmin play a well-defined role in neurochemistry. They mediate a number of events that culminate in tolerance against excitotoxicity, hippocampal neurogenesis, synaptic remodeling, neuronal plasticity, cognitive and emotional processing. Abnormalities in

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