42515
齐墩果酸
analytical standard
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关于此项目
经验公式（希尔记法）:
C30H48O3
化学文摘社编号:
分子量:
456.70
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
85151701
EC Number:
208-081-6
MDL number:
产品名称
齐墩果酸, analytical standard
InChI key
MIJYXULNPSFWEK-GTOFXWBISA-N
InChI
1S/C30H48O3/c1-25(2)14-16-30(24(32)33)17-15-28(6)19(20(30)18-25)8-9-22-27(5)12-11-23(31)26(3,4)21(27)10-13-29(22,28)7/h8,20-23,31H,9-18H2,1-7H3,(H,32,33)/t20-,21-,22+,23-,27-,28+,29+,30-/m0/s1
SMILES string
[H][C@@]12CC(C)(C)CC[C@@]1(CC[C@]3(C)C2=CC[C@]4([H])[C@@]5(C)CC[C@H](O)C(C)(C)[C@]5([H])CC[C@@]34C)C(O)=O
grade
analytical standard
assay
≥97.0% (HPLC)
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
mp
>300 °C (lit.)
application(s)
food and beverages
format
neat
storage temp.
2-8°C
Quality Level
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Application
有关合适仪器技术的更多信息，请参考产品的分析证书。如需进一步支持，请联系技术服务部门。
Biochem/physiol Actions
从药用植物分离的三萜类化合物。抗肿瘤和保肝剂。齐墩果酸具有治疗神经退行性疾病的潜力。
Packaging
无底玻璃瓶中。内含物装在插入的融合锥内。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Liangfeng Fu et al.
Organic letters, 15(7), 1622-1625 (2013-03-28)
Bardoxolone methyl (2-cyano-3,12-dioxooleane-1,9(11)-dien-28-oic acid methyl ester; CDDO-Me) (1), a synthetic oleanane triterpenoid with highly potent anti-inflammatory activity (levels below 1 nM), has completed a successful phase I clinical trial for the treatment of cancer and a successful phase II trial
Dick de Zeeuw et al.
The New England journal of medicine, 369(26), 2492-2503 (2013-11-12)
Although inhibitors of the renin-angiotensin-aldosterone system can slow the progression of diabetic kidney disease, the residual risk is high. Whether nuclear 1 factor (erythroid-derived 2)-related factor 2 activators further reduce this risk is unknown. We randomly assigned 2185 patients with
Melanie Chin et al.
American journal of physiology. Renal physiology, 304(12), F1438-F1446 (2013-04-19)
Bardoxolone methyl and related triterpenoids are well tolerated and efficacious in numerous animal models potentially relevant to patients with Type 2 diabetes and chronic kidney disease. These agents enhance glucose control and regulate lipid accumulation in rodent models of diabetes
Fei Yu et al.
Journal of medicinal chemistry, 56(11), 4300-4319 (2013-05-15)
Development of hepatitis C virus (HCV) entry inhibitors represents an emerging approach that satisfies a tandem mechanism for use with other inhibitors in a multifaceted cocktail. By screening Chinese herbal extracts, oleanolic acid (OA) was found to display weak potency
Min Song et al.
Journal of pharmaceutical and biomedical analysis, 40(1), 190-196 (2005-08-30)
A highly selective and sensitive HPLC-ESI-MS-MS method was developed for the determination of oleanolic acid in human plasma. The oleanolic acid and glycyrrhetinic acid (internal standard) were recovered from plasma with ethyl acetate liquid-liquid extraction. The organic extracts were dried
实验方案
HPTLC fingerprinting enables rapid identification of passion flower with related reference materials.
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