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蒸汽密度
3.6 (vs air)
质量水平
蒸汽压
5 mmHg ( 20 °C)
等级
purum
检测方案
≥98.0% (GC)
形式
liquid
杂质
≤2% water
折射率
n20/D 1.435 (lit.)
n20/D 1.436
bp
133 °C (lit.)
密度
0.812 g/mL at 25 °C (lit.)
SMILES字符串
CN(C)CCCN
InChI
1S/C5H14N2/c1-7(2)5-3-4-6/h3-6H2,1-2H3
InChI key
IUNMPGNGSSIWFP-UHFFFAOYSA-N
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一般描述
3-(Dimethylamino)-1-propylamine (DMAPA, N,N-dimethyl-1,3-propanediamine) is a dialkylamino alkyl amine. It has been prepared from dimethylamine and acrylonitrile and confirmed by 1H NMR. It participates in the synthesis of bio-based zwitterionic surfactants from waste cooking oil (WCO).
应用
3-(Dimethylamino)-1-propylamine (DMAPA) is suitable reagent used in the following studies:
- As a cationic moiety to form the ionic liquid, 3-(dimethylamino)-1-propylaminium formate ([DMAPA]FA) which is a potential reagent to extract protein from yeast cells.
- As an aminating agent in the palladium-catalyzed amination of aryl amines.
- In the derivatization of pullulan to form cationic pullulan.
- In the partial modification of poly(styrene-alt-maleic anhydride) to form N-substituted maleimide.
- As a test compound in the parallel synthesis of alkylamine lipidoids.
- To cleave the polyamides synthesized by solid phase methods on Boc-β-Ala-PAM resin.
- Synthesis of (N,N-dialkylamino)alkyl-2-amino benzamide by reacting with isatoic anhydride.
- As a reagent for the anomeric deacetylation of protected sugars.
- Preparation of bioreducible copolymers used in gene delivery.
其他说明
工业用途
警示用语：
Danger
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B - Skin Sens. 1 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 1
闪点(°F)
closed cup
闪点(°C)
closed cup
个人防护装备
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
法规信息
危险化学品
Liya Ge et al.
Talanta, 81(4-5), 1861-1864 (2010-05-06)
As the first attempt, ionic liquid solutions have been employed for direct extraction of proteins from yeast cells. Compared with effects of 21 different ionic liquid solutions on the extraction efficiency, 3-(dimethylamino)-1-propylaminium formate ([DMAPA]FA) was selected as the suitable ionic
A Comprehensive Mechanism for Aromatic Nucleophilic Substitution in Aprotic Solvents: Derivation of the Whole Reaction Scheme for Third Order in Amine Kinetic Law.
Alvaro CE, et al.
Physical Chemistry, 3(2), 39-47 (2013)
New antihistaminic agents: Synthesis and evaluation of h 1-antihistaminic actions of 3-[(N,N-dialkylamino) alkyl)-1, 2, 3, 4-tetrahydro-(1H)-thioquinazolin-4 (3H)-ones and their oxo analogues.
Raju MB, et al
Indian Journal of Pharmaceutical Sciences, 69(6), 853-853 (2007)
Dhananjay Jere et al.
Biomedical materials (Bristol, England), 4(2), 025020-025020 (2009-04-08)
Bioreducible disulfide linkage-employing drug conjugate has already been approved for drug delivery application, and also has shown immense potential in gene and siRNA transfection. This paper will focus on the recent developments in bioreducible polymeric systems for gene and siRNA
Exploring the potential of xanthene derivatives as trypanothione reductase inhibitors and chloroquine potentiating agents.
Chibale K, et al
Tetrahedron, 59(13), 2289-2296 (2003)
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