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Merck
CN

390062

Sigma-Aldrich

噻唑橙

Dye content ~90 %

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别名:
1-甲基-4-[(3-甲基-2(3H)-苯并噻唑基)甲基]喹啉 甲苯磺酸
经验公式(希尔记法):
C26H24N2O3S2
分子量:
476.61
MDL编号:
UNSPSC代码:
12171500
PubChem化学物质编号:
NACRES:
NA.47

形式

powder

质量水平

组成

Dye content, ~90%

mp

270 °C (dec.) (lit.)

λmax

512 nm

应用

diagnostic assay manufacturing
hematology
histology

储存温度

room temp

SMILES字符串

Cc1ccc(cc1)S([O-])(=O)=O.CN2C(\Sc3ccccc23)=C\c4cc[n+](C)c5ccccc45

InChI

1S/C19H17N2S.C7H8O3S/c1-20-12-11-14(15-7-3-4-8-16(15)20)13-19-21(2)17-9-5-6-10-18(17)22-19;1-6-2-4-7(5-3-6)11(8,9)10/h3-13H,1-2H3;2-5H,1H3,(H,8,9,10)/q+1;/p-1

InChI key

ACOJCCLIDPZYJC-UHFFFAOYSA-M

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一般描述

噻唑橙可与肽核酸连接,用于检测均质溶液中的目标核酸。它是一种染料并且具有良好网织红细胞染料的预测物理特性和生物染色特征,因此,它被作为一种用于网织红细胞分析的染料。它在与核酸结合后,特别是RNA,产生大幅的荧光增强和高量子产率。它不会发生沉淀,并且可以透过活细胞膜。

应用

噻唑橙已可用于染色并定量网织红细胞。

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


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Danitza Nébor et al.
Scientific reports, 8(1), 12793-12793 (2018-08-26)
Anemic Nan mice carry a mutation (E339D) in the second zinc finger of erythroid transcription factor KLF1. Nan-KLF1 fails to bind a subset of normal KLF1 targets and ectopically binds a large set of genes not normally engaged by KLF1
Adam D Cawte et al.
Nature communications, 11(1), 1283-1283 (2020-03-11)
RNA molecules play vital roles in many cellular processes. Visualising their dynamics in live cells at single-molecule resolution is essential to elucidate their role in RNA metabolism. RNA aptamers, such as Spinach and Mango, have recently emerged as a powerful
Costimulation blockade, busulfan, and bone marrow promote titratable macrochimerism, induce transplantation tolerance, and correct genetic hemoglobinopathies with minimal myelosuppression.
Adams AB
Journal of Immunology, 167(2), 1103-1111 (2001)
Light-up probes: thiazole orange-conjugated peptide nucleic acid for detection of target nucleic acid in homogeneous solution.
Svanvik N
Analytical Biochemistry, 281(1), 26-35 (2000)
L G Lee et al.
Cytometry, 7(6), 508-517 (1986-11-01)
The purpose of this study was to find a 488-nm excitable fluorescent dye for reticulocyte analysis by the use of fluorescence activated cell cytometry. The chemical structure of thioflavin T, a dye used for reticulocyte analysis with 457-nm excitation, was

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