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Merck
CN

35417

Supelco

Paxilline solution

100 μg/mL in acetonitrile, analytical standard

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别名:
(2R,4bS,6aS,12bS,12cR,14aS)-4b-Hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-5,6,6a,7,12,12b,12c,13,14,14a-decahydro-2H-chromeno[5′,6′:6,7]indeno[1,2-b]indol-3(4bH)-one solution
经验公式(希尔记法):
C27H33NO4
CAS号:
分子量:
435.56
EC 号:
MDL编号:
UNSPSC代码:
85151701
PubChem化学物质编号:

等级

analytical standard

质量水平

保质期

limited shelf life, expiry date on the label

浓度

100 μg/mL in acetonitrile

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

cleaning products
cosmetics
food and beverages
personal care

格式

single component solution

储存温度

−20°C

SMILES字符串

CC(C)(O)[C@H]1O[C@H]2CC[C@@]3(C)[C@@](O)(CC[C@H]4Cc5c([nH]c6ccccc56)[C@]34C)C2=CC1=O

InChI

1S/C27H33NO4/c1-24(2,30)23-20(29)14-18-21(32-23)10-11-25(3)26(4)15(9-12-27(18,25)31)13-17-16-7-5-6-8-19(16)28-22(17)26/h5-8,14-15,21,23,28,30-31H,9-13H2,1-4H3/t15-,21-,23-,25+,26+,27+/m0/s1

InChI key

ACNHBCIZLNNLRS-UBGQALKQSA-N

应用

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

象形图

FlameExclamation mark

警示用语:

Danger

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

WGK

WGK 2

闪点(°F)

35.6 °F

闪点(°C)

2.0 °C

法规信息

危险化学品

分析证书(COA)

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Bogusz Kulawiak et al.
Mitochondrion, 12(1), 169-172 (2012-01-14)
In the present study, we show that the large conductance calcium-activated potassium channel (BK(Ca) channel) inhibitor paxilline protects neuronal cells against glutamate-induced cell death. In our studies, we used HT22 mouse hippocampal cells as an experimental model and observed that
Yanping Liu et al.
Circulation research, 108(5), 566-573 (2011-01-15)
Endothelial derived hydrogen peroxide (H(2)O(2)) is a necessary component of the pathway regulating flow-mediated dilation (FMD) in human coronary arterioles (HCAs). However, H(2)O(2) has never been shown to be the endothelium-dependent transferrable hyperpolarization factor (EDHF) in response to shear stress.
De-Juan Wang et al.
PloS one, 7(8), e41499-e41499 (2012-08-29)
Depolarization-induced suppression of excitation (DSE) at parallel fiber-Purkinje cell synapse is an endocannabinoid-mediated short-term retrograde plasticity. Intracellular Ca(2+) elevation is critical for the endocannabinoid production and DSE. Nevertheless, how elevated Ca(2+) leads to DSE is unclear. We utilized cytosolic phospholipase
Joël Tabak et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(46), 16855-16863 (2011-11-18)
The electrical activity pattern of endocrine pituitary cells regulates their basal secretion level. Rat somatotrophs and lactotrophs exhibit spontaneous bursting and have high basal levels of hormone secretion, while gonadotrophs exhibit spontaneous spiking and have low basal hormone secretion. It
Wendy L Imlach et al.
Toxicon : official journal of the International Society on Toxinology, 57(5), 686-694 (2011-02-09)
The aim of this study was to compare the mode of action of the commonly used BK inhibitor paxilline with that of the more recently discovered lolitrem B. Similarities and differences in characteristics of inhibition between the two compounds were

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