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等级
analytical standard
质量水平
保质期
limited shelf life, expiry date on the label
技术
HPLC: suitable
gas chromatography (GC): suitable
mp
51-55 °C
应用
environmental
包装形式
neat
储存温度
2-8°C
SMILES字符串
BrCC(Br)(CCC#N)C#N
InChI
1S/C6H6Br2N2/c7-4-6(8,5-10)2-1-3-9/h1-2,4H2
InChI key
DHVLDKHFGIVEIP-UHFFFAOYSA-N
一般描述
Methyldibromoglutaronitrile (MDBGN) is a bromine-containing preservative and a clinically significant allergen as investigated from animal/human clinical studies.
Methyldibromoglutaronitrile can be generally used as a preservative in the cosmetic industry for many skin care products.
应用
Methyldibromoglutaronitrile may be used as an analytical reference standard for the quantification of the analyte in cosmetic products using ultra performance liquid chromatography (UPLC) coupled to inductively coupled plasma mass spectrometry (ICP-MS) and gas chromatography followed by mass spectrometry technique.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
推荐产品
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
警示用语：
Danger
危险声明
危险分类
Acute Tox. 4 Oral - Skin Corr. 1B
储存分类代码
8A - Combustible corrosive hazardous materials
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
农药列管产品
L A Fischer et al.
The British journal of dermatology, 159(5), 1138-1143 (2008-09-18)
Methyldibromoglutaronitrile (MDBGN) is a preservative, which was approved for use in cosmetics in the mid-1980s. The incidence of allergy to MDBGN rose during the 1990s, but is now decreasing due to regulatory intervention. Experimental studies with other allergens have shown
Marléne Isaksson et al.
Dermatitis : contact, atopic, occupational, drug, 18(4), 203-207 (2007-11-21)
Contact allergy to and allergic contact dermatitis from methyldibromoglutaronitrile (MDBGN) have been frequently reported since the 1990s. This study was initiated to help determine the optimal test preparation for MDBGN and to help determine the clinical relevance of such a
B C Carlsen et al.
The British journal of dermatology, 160(1), 103-106 (2008-11-19)
It is not known if reduced elicitation thresholds are evident among polysensitized individuals when using allergens to which the patients are already sensitized. Reduced elicitation thresholds may be an expression of increased reactivity in this patient group. To examine and
Manuela Pellegrini et al.
Journal of pharmaceutical and biomedical analysis, 56(5), 1112-1116 (2011-08-30)
A simple and rapid gas chromatography (GC) method with mass spectrometry (MS) detection has been developed for the determination of methyldibromo glutaronitrile (MDBGN) in cosmetic products. The presence of this preservative in commercial cosmetic samples is prohibited since 2007 because
Methyldibromoglutaronitrile (Euxyl K400): A new and important sensitizer in the United States?
Jackson M.J, et al.
Journal of the American Academy of Dermatology, 38, 934-937 (1998)
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