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About This Item
经验公式（希尔记法）:
C16H12FN3O3
CAS号:
分子量:
313.28
EC 号:
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24
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等级
analytical standard
质量水平
产品线
VETRANAL®
保质期
limited shelf life, expiry date on the label
技术
HPLC: suitable
gas chromatography (GC): suitable
应用
forensics and toxicology
pharmaceutical (small molecule)
包装形式
neat
SMILES字符串
COC(=O)Nc1nc2cc(ccc2[nH]1)C(=O)c3ccc(F)cc3
InChI
1S/C16H12FN3O3/c1-23-16(22)20-15-18-12-7-4-10(8-13(12)19-15)14(21)9-2-5-11(17)6-3-9/h2-8H,1H3,(H2,18,19,20,22)
InChI key
CPEUVMUXAHMANV-UHFFFAOYSA-N
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一般描述
Flubendazol is a broad spectrum anthelmintic, which belongs to the class of compounds known as benzimidazoles. It can be widely used in veterinary and human medicine. It mainly finds applications in deworming poultry, swine, dogs and cats.
Flubendazol is an injectable benzimidazole drug; though it is poorly absorbed it is quite effective in the treatment of trycocephalus, ascaris and oxyuriasis in both children and adults.
应用
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
VETRANAL® analytical standard can be used in the liquid chromatography coupled to mass spectrometry (LC-MS/MS) procedure, performed for the analysis of macrocyclic lactones in milk.
法律信息
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
10 - Combustible liquids
WGK
WGK 2
个人防护装备
Eyeshields, Gloves, type N95 (US)
Gabriel Rübensam et al.
Analytica chimica acta, 705(1-2), 24-29 (2011-10-04)
In this work a method is proposed and demonstrated for the analysis of the macrocyclic lactones abamectin, doramectin, eprinomectin, ivermectin and moxidectin in bovine milk by liquid chromatography coupled to mass spectrometry (LC-MS/MS) and liquid chromatography with fluorescence detection (LC-FL).
H Bártíková et al.
Journal of veterinary pharmacology and therapeutics, 33(1), 56-62 (2010-05-07)
The aim of this project was to study the influence of haemonchosis, a common parasitic infection of small ruminants caused by Haemonchus contortus, on the activity of biotransformation enzymes and on in vitro flubendazole (FLU) biotransformation in liver and small
Paul A Spagnuolo et al.
Blood, 115(23), 4824-4833 (2010-03-30)
On-patent and off-patent drugs with previously unrecognized anticancer activity could be rapidly repurposed for this new indication given their prior toxicity testing. To identify such compounds, we conducted chemical screens and identified the antihelmintic flubendazole. Flubendazole induced cell death in
W Apt
Revista medica de Chile, 118(9), 1021-1027 (1990-09-01)
New anti-helminthic drugs have appeared lately: benzimidazoles (mebendazole, flubendazol, and abendazole), praziquantel and ivermectin. Mebendazol and flubendazol are poorly absorbed and are effective for ascaris, oxyuriasis and trycocephalus both in adults and children. Abendazole is well absorbed and may be
V Krízová et al.
Journal of veterinary pharmacology and therapeutics, 32(6), 606-612 (2010-05-07)
Flubendazole (FLU) is indicated for control of helminthoses in pig and avian species (monogastric animals) and its corresponding pharmacokinetics are well known. The information on FLU's pharmacokinetic behavior in animal species with forestomach (ruminants) has been limited although the use
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