34091
氟苯达唑
VETRANAL®, analytical standard
别名:
[5-(4-氟苯甲酰)-1H-苯并咪唑-2-基]氨基甲酸甲酯, 氟苯咪唑
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关于此项目
经验公式（希尔记法）:
C16H12FN3O3
化学文摘社编号:
分子量:
313.28
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
250-624-4
MDL number:
Quality Level
InChI
1S/C16H12FN3O3/c1-23-16(22)20-15-18-12-7-4-10(8-13(12)19-15)14(21)9-2-5-11(17)6-3-9/h2-8H,1H3,(H2,18,19,20,22)
InChI key
CPEUVMUXAHMANV-UHFFFAOYSA-N
SMILES string
COC(=O)Nc1nc2cc(ccc2[nH]1)C(=O)c3ccc(F)cc3
grade
analytical standard
product line
VETRANAL®
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
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General description
Flubendazol is a broad spectrum anthelmintic, which belongs to the class of compounds known as benzimidazoles. It can be widely used in veterinary and human medicine. It mainly finds applications in deworming poultry, swine, dogs and cats.
Flubendazol is an injectable benzimidazole drug; though it is poorly absorbed it is quite effective in the treatment of trycocephalus, ascaris and oxyuriasis in both children and adults.
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
VETRANAL® analytical standard can be used in the liquid chromatography coupled to mass spectrometry (LC-MS/MS) procedure, performed for the analysis of macrocyclic lactones in milk.
Legal Information
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
10 - Combustible liquids
wgk
WGK 2
ppe
Eyeshields, Gloves, type N95 (US)
Achiral and chiral high-performance liquid chromatographic determination of flubendazole and its metabolites in biomatrices using UV photodiode-array and mass spectrometric detection
Nobilis M, et al.
Journal of Chromatography A, 1149, 112-120 (2007)
Laura Ceballos et al.
Chemotherapy, 56(5), 386-392 (2010-10-16)
Cystic echinococcosis (CE) is an important public health problem worldwide. Flubendazole, administered in tablets, has shown poor in vivo efficacy against CE in humans. However, flubendazole prepared as a solution caused a marked reduction in hydatid cysts developed in mice.
Hana Bártíková et al.
Parasitology, 139(6), 809-818 (2012-02-09)
The drug-metabolizing enzymes of some helminths can deactivate anthelmintics and therefore partially protect helminths against these drugs' toxic effect. The aim of our study was to assess the activity of the main drug-metabolizing enzymes and evaluate the metabolism of selected
Integrated pharmacological assessment of flubendazole potential for use in sheep: disposition kinetics, liver metabolism and parasite diffusion ability
Moreno.L, et al.
Journal of Veterinary Pharmacology and Therapeutics, 27, 299-308 (2004)
S Squires et al.
Veterinary parasitology, 185(2-4), 352-354 (2011-10-26)
The efficacy of a commercially available flubendazole-based product and a commercially available herbal product were compared against three species of helminth parasites of chickens: Ascaridia galli, Heterakis gallinarum and Capillaria spp. A total of 48 naturally infected chickens were used
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