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Merck
CN
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文件

安全信息

34044

Supelco

硫姆林

VETRANAL®, analytical standard

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别名:
(1S,2R,3S,4S,6R,7S,14R)-6-[(2-二乙氨乙硫基)乙酰氧基]-3-羟基-2,4,7,14-四甲基-4-乙烯基三环[5,4,3,01.8]十四烷-9-酮
经验公式（希尔记法）:
C28H47NO4S
CAS号:
55297-95-5
分子量:
493.74
EC 号:
259-580-0
UNSPSC代码:
41116107
PubChem化学物质编号:
24860813
NACRES:
NA.24

等级

analytical standard

质量水平

100

产品线

VETRANAL®

保质期

limited shelf life, expiry date on the label

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

forensics and toxicology
pharmaceutical (small molecule)

格式

neat

作用机制

enzyme | inhibits

储存温度

2-8°C

SMILES字符串

CCN(CC)CCSCC(=O)O[C@@H]1C[C@@](C)(C=C)[C@@H](O)[C@H](C)[C@@]23CC[C@@H](C)C1(C)[C@@H]2C(=O)CC3

InChI

1S/C28H47NO4S/c1-8-26(6)17-22(33-23(31)18-34-16-15-29(9-2)10-3)27(7)19(4)11-13-28(20(5)25(26)32)14-12-21(30)24(27)28/h8,19-20,22,24-25,32H,1,9-18H2,2-7H3/t19-,20+,22-,24+,25+,26-,27+,28+/m1/s1

InChI key

UURAUHCOJAIIRQ-QGLSALSOSA-N

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相关类别

一般描述

Chemical structure: macrolide
Tiamulinis a veterinary drug with very low water solubility (0.000524 mg/mL). Its mode of action involves suppressing protein synthesis in bacteria.

应用

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
For detailed application information, please see the Frequently Asked Questions (FAQ) section at the bottom of this page.

法律信息

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

危险声明

H413

预防措施声明

P273 - P501

危险分类

Aquatic Chronic 4

WGK

WGK 2

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is the best way to remove a portion of the material from the vial, in order to prepare a standard from Product 34044, Tiamulin?

    Tiamulin is a viscous liquid at room temperature, so it is a little difficult to work with. The kind of vial that is used for Product 34044-100MG-R is what Sigma-Aldrich Germany typically uses for amounts of about 10 mg to 100 mg. Tiamulin does not have a good chromophore, so we don't have an extinction coefficient for it; that is, if there were a chromophore, one might be able to quantitate it by measuring the UV absorbance of a solution.Here are our recommendations:1. Heat the vial up to 50-60°C. This will significantly reduce the viscosity of the Tiamulin.2. If there is material visible in the cap of the vial, spin it down using a small benchtop centrifuge for a few seconds. Briefly warm back up to 50-60°C if the vial cools down significantly during centrifugation.3. Using a pipetter, carefully transfer about 10 microliters of the warm liquid into a tared vial on a balance.4. Obtain an accurate weight, and use that in your calculations.As the material is needed, the vial can be heated several times to 50-60°C, without harming it. The 100 mg is roughly 100 microliters, so following the recommendations above, you should be able to obtain about 10 samples from the vial of 34044-100MG-R.

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

"Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin?
Schlunzen F, et al.
Molecular Microbiology, 54(05), 1287-1294 (2004)
K M S Islam et al.
Poultry science, 87(12), 2528-2534 (2008-11-29)
In an earlier study, the continuous medication of broiler feed with a combination of tiamulin (TIA; 20 mg/kg), chlortetracycline (CTC; 60 mg/kg), and the ionophore anticoccidial salinomycin (SAL; 60 mg/kg) caused an initial increase in BW and feed efficiency (FE;
Decreased susceptibility of MRSA ST398 to tiamulin.
Joseph E Rubin et al.
Veterinary microbiology, 151(3-4), 422-423 (2011-04-23)
Saad Gharaibeh et al.
Veterinary microbiology, 150(3-4), 379-383 (2011-03-09)
This study compares the antimicrobial susceptibility over time between two groups of Mycoplasma gallisepticum (MG) isolates from the same geographical area. Minimum inhibitory concentration of 13 antimicrobials was determined against two groups of MG isolates from chickens. Group 1 strains
Xun Pan et al.
Journal of environmental sciences (China), 23(10), 1729-1737 (2011-01-01)
This work describes a systematic approach to the development of a method for simultaneous determination of three classes of veterinary antibiotics in the suspended solids (SS) of swine wastewater, including five sulfonamides, three tetracyclines and one macrolide (tiamulin). The entire
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