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等级
analytical standard
质量水平
产品线
VETRANAL®
保质期
limited shelf life, expiry date on the label
技术
HPLC: suitable
gas chromatography (GC): suitable
应用
forensics and toxicology
pharmaceutical (small molecule)
包装形式
neat
SMILES字符串
Cn1c(CO)ncc1[N+]([O-])=O
InChI
1S/C5H7N3O3/c1-7-4(3-9)6-2-5(7)8(10)11/h2,9H,3H2,1H3
InChI key
JSAQDPJIVQMBAY-UHFFFAOYSA-N
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一般描述
HMMNI is a hydroxy metabolite of nitroimidazole antibiotics, belonging to a class of veterinary drugs with therapeutic applications in the treatment and prevention of certain bacterial and protozoal diseases in poultry and swine.
HMMNI is a major metabolite of nitroimidazole drug, dimetridazole (DMZ).
应用
HMMNI may be used as a reference standard for the determination of HMMNI in porcine liver using liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS).
HMMNI may be used as an analytical reference standard for the determination of the analyte in:
- Different matrices of swine using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) and ultra-performance liquid chromatography coupled to electrospray tandem mass spectrometry (UPLC-ESI-MS/MS).
- Biological & environmental matrices using liquid chromatography with ultraviolet detection (LC-UV).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
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Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
法律信息
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
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警示用语：
Warning
危险声明
危险分类
Carc. 2 - Muta. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 1
个人防护装备
Eyeshields, Gloves, type N95 (US)
Analytical methodologies for the determination of nitroimidazole residues in biological and environmental liquid samples: a review.
Mahugo-Santana C, et al.
Analytica Chimica Acta, 665(2), 113-122 (2010)
S Inghelbrecht et al.
Journal of veterinary pharmacology and therapeutics, 19(1), 62-67 (1996-02-01)
The anti-trichomonal efficacy and pharmacokinetics of dimetridazole were investigated in the homing pigeon (Columba livia). Dimetridazole was formulated for drinking water medication and as a prolonged-release tablet. To suppress a Trichomonas gallinae infection successfully, medicated drinking water containing dimetridazole (400
G Carignan et al.
Journal - Association of Official Analytical Chemists, 71(6), 1146-1149 (1988-11-01)
A study was conducted to monitor the elimination of dimetridazole (DMZ) and its major metabolite 2-hydroxymethyl-1-methyl-5-nitroimidazole (HMMNI) in swine plasma and tissue, using a liquid chromatographic method with electrochemical detector sensitive to 0.5 ppb. The study consisted of 2 experiments.
Determination of dimetridazole in poultry tissues and eggs using liquid chromatography-thermospray mass spectrometry.
Cannavan A and Kennedy GD
Analyst, 122(9), 963-966 (1997)
Determination of 5-nitroimidazoles and corresponding hydroxy metabolites in swine kidney by ultra-performance liquid chromatography coupled to electrospray tandem mass spectrometry.
Xia Xi, et al.
Analytica Chimica Acta, 637(1-2), 79-86 (2009)
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