所有图片(2)
别名:
2-(4-Thiazolyl)-5-benzimidazolol, 5-Hydroxy-2-(4-thiazolyl)benzimidazole
经验公式（希尔记法）:
C10H7N3OS
推荐产品
等级
analytical standard
质量水平
产品线
PESTANAL®
保质期
limited shelf life, expiry date on the label
技术
HPLC: suitable
gas chromatography (GC): suitable
应用
agriculture
environmental
forensics and toxicology
veterinary
格式
neat
SMILES字符串
Oc1ccc2[nH]c(nc2c1)-c3cscn3
InChI
1S/C10H7N3OS/c14-6-1-2-7-8(3-6)13-10(12-7)9-4-15-5-11-9/h1-5,14H,(H,12,13)
InChI key
VNENJHUOPQAPAT-UHFFFAOYSA-N
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一般描述
5-Hydroxythiabendazole present in excreta, eggs, edible tissues and milk is found to be the major metabolite of thiabendazole, an active ingredient in fungicidal preparations effective for plants. It can also be used as an anthelmintic drug, which is applicable both for humans and animals.
应用
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Thiabendazole and its metabolite 5-hydroxythiabendazole can undergo specific binding with monoclonal antibodies and can further undergo immobilization on agarose gels, which can find applications in immunoaffinity chromatography.
法律信息
PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Aquatic Acute 1
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
A Cannavan et al.
Journal of chromatography. B, Biomedical sciences and applications, 718(1), 103-113 (1998-12-01)
A novel method is presented for the determination of thiabendazole and 5-hydroxythiabendazole in animal tissues. Samples are homogenised in buffer at pH=7.0, extracted with ethyl acetate and cleaned up using CN solid-phase extraction columns. Thiabendazole and 5-hydroxythiabendazole are separated chromatographically
Immobilisation of thiabendazole specific antibodies on an agarose matrix for application in immunoaffinity chromatography
Horne E, et al.
Analyst, 124, 87-90 (1999)
S S Tai et al.
Journal - Association of Official Analytical Chemists, 73(3), 368-373 (1990-05-01)
The liquid chromatographic determination previously developed for benzimidazoles in cattle liver has been slightly modified and applied to the determination of 4 benzimidazoles in milk. Recoveries of fenbendazole (FBZ), oxfendazole (OFZ), and thiabendazole (TBZ) from milk fortified at the 10
Metabolism of thiabendazole in laying hen and lactating goats
Chukwudebe.CA, et al.
Journal of Agricultural and Food Chemistry, 42, 2964-2969 (1994)
Joseph D Jamieson et al.
Toxicology in vitro : an international journal published in association with BIBRA, 25(5), 1061-1066 (2011-04-26)
Thiabendazole (TBZ), an antihelminthic and antifungal agent, is associated with a host of adverse effects including nephrotoxicity, hepatotoxicity, and teratogenicity. Bioactivation of the primary metabolite of TBZ, 5-hydroxythiabendazole, has been proposed to yield a reactive intermediate. Here we show that
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