推荐产品
等级
analytical standard
质量水平
产品线
VETRANAL®
保质期
limited shelf life, expiry date on the label
浓度
100 μg/mL in acetonitrile
技术
HPLC: suitable
gas chromatography (GC): suitable
应用
agriculture
包装形式
single component solution
储存温度
2-8°C
SMILES字符串
[H][C@@]12CCC(=O)[C@@]1(C)CCc3c2ccc4cc(O)ccc34
InChI
1S/C18H18O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h2-5,10,16,19H,6-9H2,1H3/t16-,18-/m0/s1
InChI key
PDRGHUMCVRDZLQ-WMZOPIPTSA-N
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应用
Equilenin may be used as an analytical reference standard for the quantification of the analyte in pharmaceutical formulations using high-performance liquid chromatography (HPLC) with fluorescence and ultraviolet detection.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
法律信息
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
储存分类代码
3 - Flammable liquids
WGK
WGK 2
闪点(°F)
35.6 °F
闪点(°C)
2 °C
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
危险化学品
Yoshinori Okamoto et al.
Chemical research in toxicology, 21(5), 1120-1124 (2008-05-02)
Long-term hormone replacement therapy with equine estrogens is associated with a higher risk of breast, ovarian, and endometrial cancers. Reactive oxygen species generated through redox cycling of equine estrogen metabolites may damage cellular DNA. Such oxidative stress may be linked
Kuan-Wei Peng et al.
Chemical research in toxicology, 23(8), 1374-1383 (2010-06-15)
4-Hydroxyequilenin (4-OHEN) is a major phase I metabolite of the equine estrogens present in widely prescribed hormone replacement formulations. 4-OHEN is autoxidized to an electrophilic o-quinone that has been shown to redox cycle, generating ROS, and to covalently modify proteins
Carol A Shultz et al.
Chemical research in toxicology, 24(12), 2153-2166 (2011-09-14)
Polycyclic aromatic hydrocarbons (PAHs) are suspect human lung carcinogens and can be metabolically activated to remote quinones, for example, benzo[a]pyrene-1,6-dione (B[a]P-1,6-dione) and B[a]P-3,6-dione by the action of either P450 monooxygenase or peroxidases, and to non-K region o-quinones, for example B[a]P-7,8-dione
Shuang Ding et al.
Chemical research in toxicology, 21(9), 1739-1748 (2008-08-06)
Estrogen components of some hormone replacement formulations have been implicated in the initiation of breast cancer. Some of these formulations contain equine estrogens such as equilin and equilenin that are metabolized to the genotoxic catechol 4-hydroxyequilenin (4-OHEN). Auto-oxidation generates the
HPLC analysis of pharmaceutical estrogens in raw materials and dosage forms.
Gatti R, et al.
Journal of Pharmaceutical and Biomedical Analysis, 17(2), 337-347 (1998)
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