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About This Item
经验公式（希尔记法）:
C8H8NO5K
CAS号:
分子量:
237.25
EC 号:
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24
推荐产品
等级
analytical standard
质量水平
产品线
VETRANAL®
保质期
limited shelf life, expiry date on the label
技术
HPLC: suitable
gas chromatography (GC): suitable
应用
agriculture
clinical
environmental
forensics and toxicology
pharmaceutical (small molecule)
包装形式
neat
储存温度
2-8°C
SMILES字符串
[K+].[H][C@@]12CC(=O)N1[C@@H](C([O-])=O)C(\O2)=C\CO
InChI
1S/C8H9NO5.K/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4;/h1,6-7,10H,2-3H2,(H,12,13);/q;+1/p-1/b4-1-;/t6-,7-;/m1./s1
InChI key
ABVRVIZBZKUTMK-JSYANWSFSA-M
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一般描述
克拉维酸钾是奥沙那南的衍生物，属于β-内酰胺酶抑制剂。它可与青霉素类抗生素联合使用，使它们对β-内酰胺酶产生耐药性。
应用
该分析标准品可用于：
- 利用毛细管电泳（CE）结合电容耦合非接触式电导检测法，对药物制剂中的阿莫西林和克拉维酸钾（C4D）同时进行分析
- 建立一种稳定性指示的高效液相色谱（HPLC）法，并结合质谱（MS）技术，测定阿莫西林、克拉维酸钾及其杂质在其联合剂型中的含量
- 使用紫外分光光度法对克拉维酸钾和阿莫西林三水合物在其原料药、联合片剂制剂和人类尿液样本中进行残留分析
- 利用基于HPLC法的二极管阵列检测器（DAD），在静脉注射的同时测定美罗培南和克拉维酸钾及其降解杂质的含量
- 利用毛细管区带电泳法（CZE），测定联合市售出制剂中阿莫西林和克拉维酸的含量
生化/生理作用
β-内酰胺酶抑制剂，通常加入阿莫西林以提高其功效。
其他说明
有关合适的仪器技术的更多信息，请参阅产品′的检验报告。想要获得更多支持，请联系技术服务部。
法律信息
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险分类
Flam. Sol. 2 - Resp. Sens. 1 - Self-heat. 2 - Skin Sens. 1
补充剂危害
储存分类代码
4.2 - Pyrophoric and self-heating hazardous materials
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
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