32830
L-2,4-二氨基丁酸 二盐酸盐
≥95.0%
别名:
(2S)-2,4-Diaminobutanoic acid dihydrochloride, L-2,4-Diaminobutanoic acid dihydrochloride
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关于此项目
线性分子式:
NH2CH2CH2CH(NH2)COOH · 2HCl
化学文摘社编号:
分子量:
191.06
UNSPSC Code:
12352106
NACRES:
NA.22
PubChem Substance ID:
EC Number:
217-542-0
Beilstein/REAXYS Number:
5763078
MDL number:
产品名称
L-2,4-二氨基丁酸 二盐酸盐, ≥95.0%
InChI key
CKAAWCHIBBNLOJ-QTNFYWBSSA-N
InChI
1S/C4H10N2O2.2ClH/c5-2-1-3(6)4(7)8;;/h3H,1-2,5-6H2,(H,7,8);2*1H/t3-;;/m0../s1
SMILES string
Cl.Cl.NCC[C@H](N)C(O)=O
assay
≥95.0% (AT)
≥95.0%
optical activity
[α]20/D +14.5±1.5°, c = 3.67% in H2O
reaction suitability
reaction type: solution phase peptide synthesis
mp
197-200 °C (dec.)
solubility
water: soluble 0.5 g/10 mL
application(s)
peptide synthesis
Quality Level
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Application
L-2,4-二氨基丁酸二盐酸盐可用于通过 HPLC-FD、UHPLC-UV、UHPLC-MS 和三重四极杆串联质谱法（UHPLC-MS/MS）从二氨基酸中区分出 β-N-甲基氨基-L-丙氨酸。它适用于定量海鲜中神经毒素 β-N-甲基氨基-L-丙氨酸（BMAA）。它可用作氨基酸分析的内标
Disclaimer
可能会释放出 HCl
General description
L-2,4-二氨基丁酸二盐酸盐是非天然氨基酸衍生物。
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Liying Jiang et al.
Scientific reports, 4, 6931-6931 (2014-11-07)
The neurotoxin β-N-methylamino-L-alanine (BMAA) produced naturally by cyanobacteria, diatoms and dinoflagellates can be transferred and accumulated up the food chain, and may be a risk factor for neurodegenerative diseases. This study provides the first systematic screening of BMAA exposure of
Sun-Young An et al.
The Journal of general and applied microbiology, 55(5), 339-343 (2009-11-27)
An actinobacterial strain, 2SbT, isolated from lichen was characterized taxonomically using a polyphasic approach. Strain 2SbT was Gram-positive, strictly aerobic, rod-shaped and non-motile. Phylogenetic analysis based on 16S rRNA gene sequence revealed that strain 2SbT was located in the genus
S A Banack et al.
Toxicon : official journal of the International Society on Toxinology, 56(6), 868-879 (2010-06-22)
The cyanobacterial neurotoxin beta-N-methylamino-L-alanine (BMAA) has been associated with certain forms of progressive neurodegenerative disease, including sporadic Amyotrophic Lateral Sclerosis and Alzheimer's disease. Reports of BMAA in cyanobacterial blooms from lakes, reservoirs, and other water resources continue to be made
Maria Hoernke et al.
Biochimica et biophysica acta, 1818(7), 1663-1672 (2012-03-22)
Basic amino acids play a key role in the binding of membrane associated proteins to negatively charged membranes. However, side chains of basic amino acids like lysine do not only provide a positive charge, but also a flexible hydrocarbon spacer
Thomas Krüger et al.
Toxicon : official journal of the International Society on Toxinology, 55(2-3), 547-557 (2009-10-15)
Since diverse taxa of cyanobacteria has been linked to biosynthesis of BMAA, a controversy has arisen about the detection of neurotoxic amino acids in cyanobacteria. In this context, a novel LC-MS/MS method was developed for the unambiguous determination of beta-N-methylamino-L-alanine
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