32830
L-2,4-二氨基丁酸 二盐酸盐
≥95.0%
别名:
(2S)-2,4-Diaminobutanoic acid dihydrochloride, L-2,4-Diaminobutanoic acid dihydrochloride
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关于此项目
线性分子式:
NH2CH2CH2CH(NH2)COOH · 2HCl
化学文摘社编号:
分子量:
191.06
UNSPSC Code:
12352106
NACRES:
NA.22
PubChem Substance ID:
EC Number:
217-542-0
Beilstein/REAXYS Number:
5763078
MDL number:
产品名称
L-2,4-二氨基丁酸 二盐酸盐, ≥95.0%
InChI key
CKAAWCHIBBNLOJ-QTNFYWBSSA-N
InChI
1S/C4H10N2O2.2ClH/c5-2-1-3(6)4(7)8;;/h3H,1-2,5-6H2,(H,7,8);2*1H/t3-;;/m0../s1
SMILES string
Cl.Cl.NCC[C@H](N)C(O)=O
assay
≥95.0% (AT)
≥95.0%
optical activity
[α]20/D +14.5±1.5°, c = 3.67% in H2O
reaction suitability
reaction type: solution phase peptide synthesis
mp
197-200 °C (dec.)
solubility
water: soluble 0.5 g/10 mL
application(s)
peptide synthesis
Quality Level
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Application
L-2,4-二氨基丁酸二盐酸盐可用于通过 HPLC-FD、UHPLC-UV、UHPLC-MS 和三重四极杆串联质谱法（UHPLC-MS/MS）从二氨基酸中区分出 β-N-甲基氨基-L-丙氨酸。它适用于定量海鲜中神经毒素 β-N-甲基氨基-L-丙氨酸（BMAA）。它可用作氨基酸分析的内标
Disclaimer
可能会释放出 HCl
General description
L-2,4-二氨基丁酸二盐酸盐是非天然氨基酸衍生物。
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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The neurotoxin β-N-methylamino-L-alanine (BMAA) produced naturally by cyanobacteria, diatoms and dinoflagellates can be transferred and accumulated up the food chain, and may be a risk factor for neurodegenerative diseases. This study provides the first systematic screening of BMAA exposure of
Discovery of α,β- and α,γ-diamino acid scaffolds for the inhibition of M1 family aminopeptidases.
Rajesh Gumpena et al.
ChemMedChem, 6(11), 1971-1976 (2011-10-26)
C Müller et al.
Antimicrobial agents and chemotherapy, 51(3), 1028-1037 (2007-01-16)
Actinoplanes friuliensis produces the lipopeptide antibiotic friulimicin, which is a cyclic peptide with one exocyclic amino acid linked to a branched-chain fatty acid acyl residue. The structural relationship to daptomycin and the excellent antibacterial performance of friulimicin make the antibiotic
Paul Alan Cox et al.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases, 10 Suppl 2, 109-117 (2009-12-16)
Veterans of the 1990-1991 Gulf War have been reported to have an increased incidence of amyotrophic lateral sclerosis (ALS) compared to personnel who were not deployed. An excess of ALS cases was diagnosed in Gulf War veterans younger than 45
Sherry M Tsai et al.
Nucleic acids research, 35(1), 307-316 (2006-12-16)
Hairpin polyamide-chlorambucil conjugates containing an alpha-diaminobutyric acid (alpha-DABA) turn moiety are compared to their constitutional isomers containing the well-characterized gamma-DABA turn. Although the DNA-binding properties of unconjugated polyamides are similar, the alpha-DABA conjugates display increased alkylation specificity and decreased rate
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