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Merck
CN
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文件

安全信息

32476

Supelco

Selamectin

VETRANAL®, analytical standard

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别名:
(5Z)-25-Cyclohexyl-4′-O-de(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)avermectin A1a
经验公式（希尔记法）:
C43H63NO11
CAS号:
220119-17-5
分子量:
769.96
UNSPSC代码:
41116107
NACRES:
NA.24

等级

analytical standard

质量水平

100

产品线

VETRANAL®

保质期

limited shelf life, expiry date on the label

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

forensics and toxicology
pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES字符串

O/N=C1[C@]2([H])[C@]3(O)[C@@](C(O[C@@H]4C[C@]5(O[C@@](C/C=C(C)/[C@@H](O[C@]6([H])C[C@@H]([C@@H](O)[C@H](C)O6)OC)[C@@H](C)/C=C/C=C3\CO2)([H])C4)O[C@H](C7CCCCC7)[C@@H](C)CC5)=O)([H])C=C\1C

InChI

1S/C43H63NO11/c1-24-11-10-14-30-23-50-40-36(44-48)27(4)19-33(43(30,40)47)41(46)52-32-20-31(16-15-25(2)38(24)53-35-21-34(49-6)37(45)28(5)51-35)54-42(22-32)18-17-26(3)39(55-42)29-12-8-7-9-13-29/h10-11,14-15,19,24,26,28-29,31-35,37-40,45,47-48H,7-9,12-13,16-18,20-23H2,1-6H3/b11-10+,25-15+,30-14+,44-36-/t24-,26-,28-,31+,32-,33-,34-,35-,37-,38-,39-,40+,42+,43+/m0/s1

InChI key

AFJYYKSVHJGXSN-XHKIUTQPSA-N

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相关类别

一般描述

Selamectin (25-cyclohexyl-25-de(1-methylpropyl)-5-deoxy-22,23-dihydro-5-(hydroxyimino)-avermectin B1 monosaccharide) is a novel endectocide. It is an anti-parasitic agent and has a unique combination of safety and efficacy both in cats and dogs following both topical and oral administration. It prevents ticks and fleas, immature heartworms, ascarids and intestinal hookworms. It can be easily tolerated even at higher dosages than 22,23-dihydroavermectin B1a (DHAVM).

应用

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

法律信息

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

危险声明

H413

预防措施声明

P273 - P501

危险分类

Aquatic Chronic 4

WGK

WGK 3

法规信息

监管及禁止进口产品

分析证书(COA)

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Selamectin: a novel broad-spectrum endectocide for dogs and cats
Bishop, B. F., et al.
Veterinary Parasitology, 91 (3), 163-176 (2000)
Chandan Seth et al.
PloS one, 11(12), e0168170-e0168170 (2016-12-16)
The WNT-TCF signaling pathway participates in adult tissue homeostasis and repair, and is hyperactive in a number of human diseases including cancers of the colon. Whereas to date there are no antagonists approved for patient use, a potential problem for
Alice Melotti et al.
EMBO molecular medicine, 6(10), 1263-1278 (2014-08-22)
Constitutive activation of canonical WNT-TCF signaling is implicated in multiple diseases, including intestine and lung cancers, but there are no WNT-TCF antagonists in clinical use. We have performed a repositioning screen for WNT-TCF response blockers aiming to recapitulate the genetic
A Rúbies et al.
Food chemistry, 181, 57-63 (2015-03-22)
We present a simple method for extracting avermectines from meat, based on a QuEChERS approach followed by liquid chromatography (LC) coupled to triple quadrupole (QqQ) tandem mass spectrometry (MS/MS). The compounds considered are ivermectin, abamectin, emamectin, eprinomectin, doramectin and moxidectin.

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