所有图片(2)
About This Item
经验公式（希尔记法）:
C14H11Cl2NO3
CAS号:
分子量:
312.15
Beilstein:
4198042
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24
推荐产品
等级
analytical standard
质量水平
产品线
VETRANAL®
保质期
limited shelf life, expiry date on the label
技术
HPLC: suitable
gas chromatography (GC): suitable
应用
forensics and toxicology
pharmaceutical (small molecule)
包装形式
neat
储存温度
2-8°C
SMILES字符串
OC(=O)Cc1ccccc1Nc2c(Cl)cc(O)cc2Cl
InChI
1S/C14H11Cl2NO3/c15-10-6-9(18)7-11(16)14(10)17-12-4-2-1-3-8(12)5-13(19)20/h1-4,6-7,17-18H,5H2,(H,19,20)
InChI key
KGVXVPRLBMWZLG-UHFFFAOYSA-N
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一般描述
4′-羟基双氯芬酸是双氯芬酸的一种代谢物，双氯芬酸是一种用于人和兽药的非甾体类抗炎药（NSAID）。
双氯芬酸的 CYP2C9 代谢物。
应用
4′-羟基双氯芬酸可用作分析参考标准品，用于通过高效液相色谱/紫外法测定大鼠血清中的分析物。
有关合适仪器技术的更多信息，请参考产品′s分析证书。如需进一步支持，请联系技术服务。
法律信息
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险分类
Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Efficient high performance liquid chromatograph/ultraviolet method for determination of diclofenac and 4?-hydroxydiclofenac in rat serum.
Kaphalia L, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 830(2), 231-237 (2006)
Lian-Hua Xu et al.
Applied microbiology and biotechnology, 99(7), 3081-3091 (2014-10-25)
Diclofenac is a nonsteroidal anti-inflammatory drug. It undergoes hydroxylation by mammalian cytochrome P450 enzymes at 4'- and/or 5'-positions. A bacterial P450 enzyme, CYP105D7 from Streptomyces avermitilis, has been shown to catalyze hydroxylation of 1-deoxypentalenic acid and an isoflavone daidzein. Here
M-Y Lee et al.
The pharmacogenomics journal, 14(4), 343-349 (2013-12-11)
Cytochrome P450 2C9 (CYP2C9) metabolizes many clinically important drugs including warfarin and diclofenac. We have recently reported a new allelic variant, CYP2C9*35, found in a warfarin hypersensitive patient with Arg125Leu and Arg144Cys mutations. Here, we have investigated the molecular basis
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