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经验公式(希尔记法):
C37H42F2N8O4
化学文摘社编号:
分子量:
700.78
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
产品名称
泊沙康唑标准液, VETRANAL®, analytical standard
InChI
1S/C37H42F2N8O4/c1-3-35(26(2)48)47-36(49)46(25-42-47)31-7-5-29(6-8-31)43-14-16-44(17-15-43)30-9-11-32(12-10-30)50-20-27-19-37(51-21-27,22-45-24-40-23-41-45)33-13-4-28(38)18-34(33)39/h4-13,18,23-27,35,48H,3,14-17,19-22H2,1-2H3/t26-,27+,35-,37-/m0/s1
SMILES string
CC[C@@H]([C@H](C)O)N1N=CN(C1=O)c2ccc(cc2)N3CCN(CC3)c4ccc(OC[C@@H]5CO[C@@](C5)(Cn6cncn6)c7ccc(F)cc7F)cc4
InChI key
RAGOYPUPXAKGKH-XAKZXMRKSA-N
grade
analytical standard
product line
VETRANAL®
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
clinical testing
format
neat
Quality Level
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General description
泊沙康唑(posaconazole)是唑类抗真菌药,最常用于治疗接合菌感染。
Legal Information
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
Application
有关合适的仪器技术的更多信息,请参阅产品′的检验报告。想要获得更多支持,请联系技术服务部。
泊沙康唑也可作为HPLC分析的参考标准品,定量分析人血浆来源的泊沙康唑。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Michael N Trinh et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(1), 89-94 (2016-12-21)
Niemann-Pick C1 (NPC1), a membrane protein of lysosomes, is required for the export of cholesterol derived from receptor-mediated endocytosis of LDL. Lysosomal cholesterol export is reportedly inhibited by itraconazole, a triazole that is used as an antifungal drug [Xu et
Johanna Rhodes et al.
Emerging microbes & infections, 7(1), 43-43 (2018-03-30)
Candida auris was first described in 2009, and it has since caused nosocomial outbreaks, invasive infections, and fungaemia across at least 19 countries on five continents. An outbreak of C. auris occurred in a specialized cardiothoracic London hospital between April
Sophida Boonsathorn et al.
Clinical pharmacokinetics, 58(1), 53-61 (2018-04-22)
The objectives of this study were to investigate the population pharmacokinetics of posaconazole in immunocompromised children, evaluate the influence of patient characteristics on posaconazole exposure and perform simulations to recommend optimal starting doses. Posaconazole plasma concentrations from paediatric patients undergoing
Ming Zhang et al.
Chinese medical journal, 130(6), 665-668 (2017-03-18)
During the past decades, the incidence of invasive aspergillosis (IA) caused by Aspergillus fumigatus has increased dramatically. The aims of this study were to investigate the susceptibility of clinical isolates of A. fumigatus to triazole and the underlying cyp51A mutations
Simultaneous quantification of voriconazole and posaconazole in human plasma by high-performance liquid chromatography with ultra-violet detection.
Chhun, Stephanie, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 852.1 , 223-228 (2007)
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