30925
虫草素
≥98.0% (HPLC)
别名:
3′-脱氧腺苷
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关于此项目
经验公式（希尔记法）:
C10H13N5O3
化学文摘社编号:
分子量:
251.24
EC Number:
200-791-4
UNSPSC Code:
12352203
PubChem Substance ID:
Beilstein/REAXYS Number:
35194
MDL number:
InChI key
OFEZSBMBBKLLBJ-BAJZRUMYSA-N
InChI
1S/C10H13N5O3/c11-8-7-9(13-3-12-8)15(4-14-7)10-6(17)1-5(2-16)18-10/h3-6,10,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,10+/m0/s1
SMILES string
Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)C[C@H]3O
assay
≥98.0% (HPLC)
mp
225-229 °C
antibiotic activity spectrum
fungi
mode of action
DNA synthesis | interferes, enzyme | inhibits
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General description
Chemical structure: nucleoside
Biochem/physiol Actions
虫草素是一种腺苷类似物，易于转化为5′-三磷酸虫草素；可用于RNA的3′-端标记。
Other Notes
Starting material for the synthesis of cordycepin triphosphate, an inhibitor of replicative synthesis
法规信息
新产品
此项目有
Hardeep S Tuli et al.
Life sciences, 93(23), 863-869 (2013-10-15)
Cytotoxic nucleoside analogues were the first chemotherapeutic agents for cancer treatment. Cordycepin, an active ingredient of the insect fungus Cordyceps militaris, is a category of compounds that exhibit significant therapeutic potential. Cordycepin has many intracellular targets, including nucleic acid (DNA/RNA)
Wei Su et al.
RNA (New York, N.Y.), 19(1), 1-16 (2012-11-29)
Metazoan replication-dependent histone mRNAs are only present in S-phase, due partly to changes in their stability. These mRNAs end in a unique stem-loop (SL) that is required for both translation and cell-cycle regulation. Previous studies showed that histone mRNA degradation
Thiyagarajan Ramesh et al.
Experimental gerontology, 47(12), 979-987 (2012-09-25)
Free radical-induced oxidative damage is considered to be the most important consequence of the aging process. The activities and capacities of antioxidant systems of cells decline with increased age, leading to the gradual loss of pro-oxidant/antioxidant balance and resulting in
Alexander Kondrashov et al.
RNA (New York, N.Y.), 18(12), 2236-2250 (2012-11-03)
Cordycepin (3' deoxyadenosine) has long been used in the study of in vitro assembled polyadenylation complexes, because it terminates the poly(A) tail and arrests the cleavage complex. It is derived from caterpillar fungi, which are highly prized in Chinese traditional
R I Gumport et al.
Biochemistry, 15(13), 2804-2809 (1976-06-29)
A structural analogue of ATP, 3'-deoxyadenosine triphosphate (3'-dATP), has been synthesized from cordycepin (3'-deoxyadenosine), characterized, and determined to be an inhibitor of ATP-dependent DNA synthesis in Escherichia coli cells which have been reduced permeable to nucleoside triphosphates by treatment with
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