301310
2-Ethyl-2-thiopseudourea hydrobromide
98%
别名:
S-Ethylisothiourea hydrobromide
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关于此项目
线性分子式:
C2H5SC(=NH)NH2 · HBr
化学文摘社编号:
分子量:
185.09
UNSPSC Code:
12171500
PubChem Substance ID:
MDL number:
InChI
1S/C3H8N2S.BrH/c1-2-6-3(4)5;/h2H2,1H3,(H3,4,5);1H
SMILES string
Br.CCSC(N)=N
InChI key
SWXXKWPYNMZFTE-UHFFFAOYSA-N
assay
98%
form
powder or crystals
mp
88-90 °C (lit.)
application(s)
diagnostic assay manufacturing
hematology
histology
storage temp.
room temp
Application
Reagent used in the synthesis of pyrimidines.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
E Alhan et al.
The European journal of surgery = Acta chirurgica, 164(9), 697-702 (1998-09-05)
To investigate the effects of the constitutive nitric oxide (NO) synthase inhibitor NG-nitro-L-arginine methyl ester (L-Name) and the inducible NO synthase inhibitor amino ethyl-isothiourea (AE-ITU) on acute necrotising pancreatitis (ANP) in rats. Laboratory study. Medical school, Turkey. Morbidity, mortality, effects
R L Rairigh et al.
The Journal of clinical investigation, 101(1), 15-21 (1998-02-14)
Nitric oxide (NO) produced by NO synthase (NOS) modulates fetal pulmonary vascular tone and contributes to the fall in pulmonary vascular resistance (PVR) at birth. Although the inducible (type II) NOS isoform is present in human and rat fetal lungs
T Muraki et al.
Japanese journal of pharmacology, 70(3), 269-271 (1996-03-01)
By dye leakage in mouse skin, we evaluated the inhibition of proinflammatory stimuli-induced plasma extravasation by a putative inhibitor of inducible nitric oxide synthase, S-ethylisothiourea. A low dose of S-ethylisothiourea (5 micrograms/kg) mimicked aminoguanidine in inhibiting the plasma extravasation elicited
Mihoko N Nakashima et al.
Journal of pharmacological sciences, 91(1), 47-52 (2003-04-11)
The possible role of nitric oxide (NO) in anxiety following transient cerebral ischemia by a 10-min bilateral carotid occlusion was examined in mice. Two days after the ischemia, mice showed a significant decrease in time spent on the open arms
W K Alderton et al.
The Biochemical journal, 332 ( Pt 1), 195-201 (1998-05-13)
Nitric oxide synthases (NOS) have a bidomain structure comprised of an N-terminal oxygenase domain and a C-terminal reductase domain. The oxygenase domain binds haem, (6R)-5,6,7,8-tetrahydro-l-biopterin (tetrahydrobiopterin) and arginine, is the site where nitric oxide synthesis takes place and contains determinants
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