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Merck
CN

26391

Sigma-Aldrich

氯磺酰异氰酸酯

purum, ≥99.0% (AT)

别名:

N-碳酰氨磺酰基氯, CSI

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About This Item

线性分子式:
ClSO2NCO
CAS号:
分子量:
141.53
Beilstein:
1237247
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:

蒸汽压

5.57 psi ( 20 °C)

等级

purum

方案

≥99.0% (AT)

折射率

n20/D 1.447 (lit.)

沸点

107 °C (lit.)

mp

−44 °C (lit.)

密度

1.626 g/mL at 25 °C (lit.)

SMILES字符串

ClS(=O)(=O)N=C=O

InChI

1S/CClNO3S/c2-7(5,6)3-1-4

InChI key

WRJWRGBVPUUDLA-UHFFFAOYSA-N

基因信息

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其他说明

已知的最活泼异氰酸酯。综述

替代产品

产品编号
说明
价格

警示用语:

Danger

危险分类

Acute Tox. 4 Oral - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1

补充剂危害

储存分类代码

8A - Combustible corrosive hazardous materials

WGK

WGK 3

闪点(°F)

>230.0 °F

闪点(°C)

> 110 °C

个人防护装备

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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J.K. Rasmussen et al.
Chemical Reviews, 76, 389-389 (1976)
D.N. Dhar et al.
Synthesis, 437-437 (1986)
G Crassous et al.
Biomaterials, 5(3), 153-156 (1984-05-01)
In this paper we report the preparation of a new asymmetric semipermeable styrene-isoprene-styrene block-copolymer membrane. Its modification by addition of gaseous N-chlorosulphonylisocyanate alters neither its permselectivity nor its water permeability rate. This modified membrane possesses an antithrombic activity which depends
C P Sharma et al.
Biomaterials, medical devices, and artificial organs, 12(3-4), 215-233 (1984-01-01)
Natural rubber with C = C bonds had been modified by reaction with chlorosulfonyl isocyanate (CSI) and 70% of the products were obtained, which yielded polyelectrolyte on treatment with NaOH, having sulfamate and carboxylate groups. The polyelectrolyte showed anticoagulant activity.
J A Picard et al.
Journal of medicinal chemistry, 39(6), 1243-1252 (1996-03-15)
Several series of acyl-CoA:cholesterol O-acyltransferase inhibitors were prepared by the stepwise addition of nitrogen, oxygen, and sulfur nucleophiles to N-chlorosulfonyl isocyanate. The (aminosulfonyl)ureas 3-44 were the most potent inhibitors in vitro, with several compounds having IC50 values < 1 microM.

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