26391
氯磺酰异氰酸酯
purum, ≥99.0% (AT)
别名:
N-碳酰氨磺酰基氯, CSI
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关于此项目
线性分子式:
ClSO2NCO
化学文摘社编号:
分子量:
141.53
EC Number:
214-715-2
UNSPSC Code:
12352100
PubChem Substance ID:
Beilstein/REAXYS Number:
1237247
MDL number:
InChI key
WRJWRGBVPUUDLA-UHFFFAOYSA-N
InChI
1S/CClNO3S/c2-7(5,6)3-1-4
SMILES string
ClS(=O)(=O)N=C=O
vapor pressure
5.57 psi ( 20 °C)
grade
purum
assay
≥99.0% (AT)
refractive index
n20/D 1.447 (lit.)
bp
107 °C (lit.)
mp
−44 °C (lit.)
density
1.626 g/mL at 25 °C (lit.)
Gene Information
human ... ABCB1(5243), FPR1(2357)
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Other Notes
已知的最活泼异氰酸酯。综述
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1
supp_hazards
存储类别
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
>230.0 °F
flash_point_c
> 110 °C
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
法规信息
新产品
此项目有
D.N. Dhar et al.
Synthesis, 437-437 (1986)
J.K. Rasmussen et al.
Chemical Reviews, 76, 389-389 (1976)
G Crassous et al.
Biomaterials, 5(3), 153-156 (1984-05-01)
In this paper we report the preparation of a new asymmetric semipermeable styrene-isoprene-styrene block-copolymer membrane. Its modification by addition of gaseous N-chlorosulphonylisocyanate alters neither its permselectivity nor its water permeability rate. This modified membrane possesses an antithrombic activity which depends
C P Sharma et al.
Biomaterials, medical devices, and artificial organs, 12(3-4), 215-233 (1984-01-01)
Natural rubber with C = C bonds had been modified by reaction with chlorosulfonyl isocyanate (CSI) and 70% of the products were obtained, which yielded polyelectrolyte on treatment with NaOH, having sulfamate and carboxylate groups. The polyelectrolyte showed anticoagulant activity.
J A Picard et al.
Journal of medicinal chemistry, 39(6), 1243-1252 (1996-03-15)
Several series of acyl-CoA:cholesterol O-acyltransferase inhibitors were prepared by the stepwise addition of nitrogen, oxygen, and sulfur nucleophiles to N-chlorosulfonyl isocyanate. The (aminosulfonyl)ureas 3-44 were the most potent inhibitors in vitro, with several compounds having IC50 values < 1 microM.
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