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Merck
CN

25745

Sigma-Aldrich

氯喹 二磷酸盐

≥96.0% (TLC)

别名:

N4-(7-氯-4-喹啉基)-N1,N1-二甲基-1,4-戊二胺 二磷酸盐

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About This Item

经验公式(希尔记法):
C18H26ClN3 · 2H3PO4
CAS号:
分子量:
515.86
Beilstein:
4223142
EC 号:
MDL编号:
UNSPSC代码:
12161501

方案

≥96.0% (TLC)

杂质

≤3% water

溶解性

H2O: 50 mg/mL, clear

作用机制

enzyme | inhibits

SMILES字符串

OP(O)(O)=O.OP(O)(O)=O.CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12

InChI

1S/C18H26ClN3.2H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;2*1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);2*(H3,1,2,3,4)

InChI key

QKICWELGRMTQCR-UHFFFAOYSA-N

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其他说明

Lysosomotropic drug

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D.D. Hong
Anal. Profiles Drug Subst., 5, 61-61 (1976)
Ingeborg Walter-Sack et al.
European journal of clinical pharmacology, 65(2), 179-189 (2008-09-24)
Methylene blue (MB) has recently been reevaluated for malaria treatment. With the aim of excluding treatment failures due to low bioavailability, we have investigated the absolute bioavailability of MB given as an aqueous oral formulation and its interaction with chloroquine
Poonuch Muhamad et al.
Malaria journal, 10, 44-44 (2011-02-18)
In Thailand, the proportion of Plasmodium vivax infection has become equal to Plasmodium falciparum. Reports of a trend of gradual decline of in vitro sensitivity of P. vivax to chloroquine in some areas of the country, together with accumulating evidences
Luciana Duarte Rodrigues et al.
Arquivos brasileiros de oftalmologia, 72(3), 313-320 (2009-08-12)
To evaluate different diagnostic methods for high risk chloroquine retinopathy due to prolonged use of chloroquine (more than 5 years) by systemic lupus erythematosus patients. Seventy-two eyes of 36 consecutive patients, followed in the Division of Rheumatology, School of Medicine
Rebecca A Clewell et al.
Toxicology and applied pharmacology, 237(3), 366-374 (2009-04-28)
Chloroquine (CQ), a drug that has been used extensively for the prevention and treatment of malaria, is currently considered safe for use during pregnancy. However, CQ has been shown to disrupt steroid homeostasis in adult rats and similar compounds, such

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