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方案
≥96.0% (TLC)
杂质
≤3% water
溶解性
H2O: 50 mg/mL, clear
作用机制
enzyme | inhibits
SMILES字符串
OP(O)(O)=O.OP(O)(O)=O.CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12
InChI
1S/C18H26ClN3.2H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;2*1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);2*(H3,1,2,3,4)
InChI key
QKICWELGRMTQCR-UHFFFAOYSA-N
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其他说明
This product has been replaced by C6628-SIGMA | Chloroquine diphosphate salt solid, ≥98%
Lysosomotropic drug
法规信息
新产品
Anal. Profiles Drug Subst., 5, 61-61 (1976)
European journal of clinical pharmacology, 65(2), 179-189 (2008-09-24)
Methylene blue (MB) has recently been reevaluated for malaria treatment. With the aim of excluding treatment failures due to low bioavailability, we have investigated the absolute bioavailability of MB given as an aqueous oral formulation and its interaction with chloroquine
Malaria journal, 10, 44-44 (2011-02-18)
In Thailand, the proportion of Plasmodium vivax infection has become equal to Plasmodium falciparum. Reports of a trend of gradual decline of in vitro sensitivity of P. vivax to chloroquine in some areas of the country, together with accumulating evidences
Arquivos brasileiros de oftalmologia, 72(3), 313-320 (2009-08-12)
To evaluate different diagnostic methods for high risk chloroquine retinopathy due to prolonged use of chloroquine (more than 5 years) by systemic lupus erythematosus patients. Seventy-two eyes of 36 consecutive patients, followed in the Division of Rheumatology, School of Medicine
Toxicology and applied pharmacology, 237(3), 366-374 (2009-04-28)
Chloroquine (CQ), a drug that has been used extensively for the prevention and treatment of malaria, is currently considered safe for use during pregnancy. However, CQ has been shown to disrupt steroid homeostasis in adult rats and similar compounds, such
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