等级
analytical standard
质量水平
蒸汽密度
3.04 (vs air)
蒸汽压
0.43 mmHg ( 20 °C)
检测方案
≥99.5% (GC)
自燃温度
824 °F
保质期
limited shelf life, expiry date on the label
expl. lim.
10 %
技术
HPLC: suitable
gas chromatography (GC): suitable
折射率
n20/D 1.398 (lit.)
bp
162 °C (lit.)
mp
−6-−3 °C (lit.)
密度
0.964 g/mL at 25 °C (lit.)
应用
cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
格式
neat
SMILES字符串
CCCC(O)=O
InChI
1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)
InChI key
FERIUCNNQQJTOY-UHFFFAOYSA-N
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一般描述
丁酸是一种含有四个碳的饱和短链脂肪酸。它通常以酯的形式存在于动物脂肪和植物油中。它是一种有效的细胞分化剂，也具有抗增殖活性。在培养的哺乳动物细胞中，它会影响生长速度、形态和基因表达。它还诱导细胞凋亡。
应用
该分析标准也可按如下方式使用：
- 高效液相色谱法（HPLC）与紫外检测相结合的方法的开发和验证，用于测定细菌培养样品中液-液萃取（LLE）后的四种短链脂肪酸甲酸—、乙酸、丙酸、丁酸和乳酸
- 采用高效液相色谱-折射率检测器和气相色谱-火焰离子化检测器同时分析韩国传统发酵豆酱（doenjang，大酱）18 个样品中的 10 种挥发性和非挥发性有机酸
- 采用反相高效液相色谱（HPLC）和毛细管电泳（CE）结合二极管阵列检测（DAD）测定酸性木薯淀粉废水样品中的丁酸、乳酸、乙酸和丙酸
- 采用气相色谱法结合火焰离子化检测器（GC-FID）对小鼠结肠生物样品中 6 种短链脂肪酸乙酸—、丙酸、丁酸、异丁酸、戊酸和异戊酸进行多残留分析
- 采用聚吡咯纳米纤维从儿童尿液样本中提取 8 种短链脂肪酸的填充纤维固相萃取（PFSPE），用于气相色谱-质谱分析（GC-MS）定量
- 采用气相色谱-质谱联用技术对大枣提取物中 76 种挥发性化合物进行多残留分析
其他说明
有关合适的仪器技术的更多信息，请参阅产品′的检验报告。想要获得更多支持，请联系技术服务部。
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警示用语：
Danger
危险声明
危险分类
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B
WGK
WGK 1
闪点(°F)
closed cup
闪点(°C)
closed cup
个人防护装备
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
法规信息
危险化学品
Butyric acid: a small fatty acid with diverse biological functions.
K N Prasad
Life sciences, 27(15), 1351-1358 (1980-10-13)
H M Chen et al.
Clinical chemistry, 35(1), 74-76 (1989-01-01)
We describe a procedure for preparing fecal samples for determination of volatile fatty acids (VFAs) by gas-liquid chromatography (GLC) and "high-performance" liquid chromatography (HPLC). The simple, one-step procedure involves only ultrafiltration through a membrane with a molecular-mass cutoff of 3000
Amita Patnaik et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 8(7), 2142-2148 (2002-07-13)
Pivaloyloxymethyl butyrate (AN-9), an acyloxyalkyl ester prodrug of butyric acid (BA), has demonstrated greater potency than BA at inducing malignant cell differentiation and tumor growth inhibition and has demonstrated more favorable toxicological, pharmacological, and pharmaceutical properties than BA in preclinical
Shomik Sengupta et al.
Journal of gastroenterology and hepatology, 21(1 Pt 2), 209-218 (2006-02-08)
Butyrate, the four-carbon fatty acid, is formed in the human colon by bacterial fermentation of carbohydrates (including dietary fiber), and putatively suppresses colorectal cancer (CRC). Butyrate has diverse and apparently paradoxical effects on cellular proliferation, apoptosis and differentiation that may
Carlo F M Welters et al.
Diseases of the colon and rectum, 45(5), 621-627 (2002-05-11)
Inflammation is a constant finding in the ileal reservoir of patients with an ileal pouch-anal anastomosis and is associated with decreased fecal concentrations of the short chain fatty acid butyrate, increased fecal pH, changes in fecal flora, and increased concentrations
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