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Merck
CN

15450

Sigma-Aldrich

BOC-亮氨酸-OH 水合物

≥99.0% (HPLC)

别名:

BOC- L -亮氨酸

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About This Item

线性分子式:
(CH3)2CHCH2CH(COOH)NHCOOC(CH3)3 xH2O
分子量:
231.29 (anhydrous basis)
EC 号:
MDL编号:
UNSPSC代码:
12352209
eCl@ss:
32160406
PubChem化学物质编号:
NACRES:
NA.22

质量水平

方案

≥99.0% (HPLC)

表单

solid

旋光性

[α]20/D −25±0.5°, c = 2% in acetic acid

反应适用性

reaction type: Boc solid-phase peptide synthesis
reaction type: C-H Activation
reagent type: ligand
reaction type: Peptide Synthesis

mp

85-90 °C

应用

peptide synthesis

官能团

amine
carboxylic acid

SMILES字符串

CC(C)C[C@H](NC(OC(C)(C)C)=O)C(O)=O

InChI

1S/C11H21NO4/c1-7(2)6-8(9(13)14)12-10(15)16-11(3,4)5/h7-8H,6H2,1-5H3,(H,12,15)(H,13,14)/t8-/m0/s1

InChI key

MDXGYYOJGPFFJL-QMMMGPOBSA-N

应用

Boc-Leu-OH(Boc-L-亮氨酸)被用于合成强效细胞毒素PM-94128
Boc保护的亮氨酸(Boc-Leu-OH)可用于产生组合肽文库,并也可用于合成肽模型以研究结构-活性关系。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Multicyclic polypeptide model compounds. 1. Synthesis of a tricyclic amphiphilic. alpha.-helical peptide using an oxime resin, segment-condensation approach.
Osapay G, et al.
Journal of the American Chemical Society, 112(16), 6046-6051 (1990)
Screening of mixture combinatorial libraries for chiral selectors: a reciprocal chromatographic approach using enantiomeric libraries.
Wu Y, et al.
Analytical Chemistry, 71(9), 1688-1691 (1999)
Masaru Enomoto et al.
The Journal of organic chemistry, 74(19), 7566-7569 (2009-09-03)
The enantioselective total synthesis of PM-94128, a potent cytotoxin of microbial origin, was accomplished by a concise nine-step sequence of reactions in 14% overall yield from N-Boc-l-leucine. The synthesis of Y-05460M-A, a one-carbon lower homologue of PM-94128, was also achieved
The synthesis and screening of a combinatorial peptide library for affinity ligands for glycosylated haemoglobin1.
Chen B, et al.
Biosensors And Bioelectronics, 13(7-8), 779-785 (1998)
Hyun-Woong Cho et al.
PloS one, 14(6), e0217745-e0217745 (2019-06-21)
The aim of this study was to investigate the short-term efficacy and safety of Poly-gamma-glutamic acid (γ-PGA) and the immunologic changes in patients with CIN 1. Participants were randomly assigned to one of two groups and orally treated with placebo

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