所有图片(1)
About This Item
线性分子式:
(CH3)2CHCH2CH(COOH)NHCOOC(CH3)3 xH2O
分子量:
231.29 (anhydrous basis)
EC 号:
MDL编号:
UNSPSC代码:
12352209
eCl@ss:
32160406
PubChem化学物质编号:
NACRES:
NA.22
质量水平
检测方案
≥99.0% (HPLC)
形式
solid
旋光性
[α]20/D −25±0.5°, c = 2% in acetic acid
反应适用性
reaction type: Boc solid-phase peptide synthesis
reaction type: C-H Activation
reagent type: ligand
reaction type: Peptide Synthesis
mp
85-90 °C
应用
peptide synthesis
官能团
amine
carboxylic acid
SMILES字符串
CC(C)C[C@H](NC(OC(C)(C)C)=O)C(O)=O
相关类别
应用
Boc-Leu-OH（Boc-L-亮氨酸）被用于合成强效细胞毒素PM-94128。
Boc保护的亮氨酸（Boc-Leu-OH）可用于产生组合肽文库，并也可用于合成肽模型以研究结构-活性关系。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Multicyclic polypeptide model compounds. 1. Synthesis of a tricyclic amphiphilic. alpha.-helical peptide using an oxime resin, segment-condensation approach.
Osapay G, et al.
Journal of the American Chemical Society, 112(16), 6046-6051 (1990)
Screening of mixture combinatorial libraries for chiral selectors: a reciprocal chromatographic approach using enantiomeric libraries.
Wu Y, et al.
Analytical Chemistry, 71(9), 1688-1691 (1999)
Masaru Enomoto et al.
The Journal of organic chemistry, 74(19), 7566-7569 (2009-09-03)
The enantioselective total synthesis of PM-94128, a potent cytotoxin of microbial origin, was accomplished by a concise nine-step sequence of reactions in 14% overall yield from N-Boc-l-leucine. The synthesis of Y-05460M-A, a one-carbon lower homologue of PM-94128, was also achieved
The synthesis and screening of a combinatorial peptide library for affinity ligands for glycosylated haemoglobin1.
Chen B, et al.
Biosensors And Bioelectronics, 13(7-8), 779-785 (1998)
Hyun-Woong Cho et al.
PloS one, 14(6), e0217745-e0217745 (2019-06-21)
The aim of this study was to investigate the short-term efficacy and safety of Poly-gamma-glutamic acid (γ-PGA) and the immunologic changes in patients with CIN 1. Participants were randomly assigned to one of two groups and orally treated with placebo
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