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Merck
CN

05238

Supelco

红霉素 A 烯醇醚

analytical standard

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About This Item

经验公式(希尔记法):
C37H65NO12
CAS号:
分子量:
715.91
UNSPSC代码:
41116107
NACRES:
NA.24

等级

analytical standard

质量水平

检测方案

≥95% (HPLC)

保质期

limited shelf life, expiry date on the label

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

forensics and toxicology
pharmaceutical (small molecule)
veterinary

格式

neat

SMILES字符串

CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H](C3O)N(C)C)[C@@]4(C)CC(C)=C(O4)[C@H](C)[C@@H](O)[C@]1(C)O

InChI

1S/C37H65NO12/c1-14-25-37(10,43)30(40)20(4)28-18(2)16-36(9,50-28)32(49-34-27(39)24(38(11)12)15-19(3)45-34)21(5)29(22(6)33(42)47-25)48-26-17-35(8,44-13)31(41)23(7)46-26/h19-27,29-32,34,39-41,43H,14-17H2,1-13H3/t19-,20+,21+,22-,23+,24+,25-,26+,27-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1

InChI key

JFVYXJKGJMUGRG-KJPZRSJGSA-N

一般描述

Erythromycin A enol ether (EAEN) is an acidic degradation product of erythromycin A (EA) which is grouped under the macrolide antibiotic class of compounds.

应用

EAEN has been used for the analysis of EAEN as degradation product of EA in honey by ultra-performance liquid chromatography equipped with tandem quadrupole mass spectrometer (UPLC-MS/MS) with positive electrospray ionisation (ESI) operating on multiple reaction monitoring (MRM) mode and in rat′s blood plasma, serum and human urine by high performance liquid chromatography-coulometric assay. It may be used as a reference standard for the detection of EAEN in erythromycin fractions by isocratic LC with evaporative light scattering detection (ELSD) and ion trap MS and in commercial erythromycin samples by LC-MS/MS.

包装

Bottomless glass bottle. Contents are inside inserted fused cone.

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

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分析证书(COA)

Lot/Batch Number

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Degradation of erythromycin in honey and selection of suitable marker residues for food safety analysis.
Thompson TS and van den Heever JP
Food Chemistry, 133(4), 1510-1520 (2012)
K Yamashita et al.
Journal of chromatography, 616(1), 144-150 (1993-06-23)
A sensitive high-performance liquid chromatographic (HPLC) method using column switching is described for the determination of EM523 (I), a new erythromycin derivative, in human plasma and urine. The analyte was extracted from alkalinized plasma or urine with a mixture of
Y Shiba et al.
Gastroenterology, 110(1), 241-250 (1996-01-01)
EM523, a nonpeptide motilin agonist, is being developed for clinical use to improve delayed gastric emptying. The aim of this study was to examine the effect of EM523 on endogenous release of gut and pancreatic hormones in conscious dogs. Motility
Determination of erythromycin and related substances in commercial samples using liquid chromatography/ion trap mass spectrometry.
Deubel A, et al.
Journal of Chromatography A, 1136(1), 39-47 (2006)
T L Peeters et al.
Biochemical and biophysical research communications, 198(2), 411-416 (1994-01-28)
Studies on the physiological role of motilin, and more recently, on the relationship between motilin and erythromycin A, have been hampered by the lack of antagonists. We now have discovered such a compound. ANQ-11125 displaces motilin bound to an homogenate

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