04704
环氧丙酰胺
analytical standard
别名:
Oxiranecarboxamide
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关于此项目
经验公式（希尔记法）:
C3H5NO2
化学文摘社编号:
分子量:
87.08
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
227-163-2
Beilstein/REAXYS Number:
227 163 2
MDL number:
SMILES string
NC(=O)C1CO1
InChI
1S/C3H5NO2/c4-3(5)2-1-6-2/h2H,1H2,(H2,4,5)
InChI key
FMAZQSYXRGRESX-UHFFFAOYSA-N
grade
analytical standard
assay
≥95% (qNMR)
shelf life
limited shelf life, expiry date on the label
application(s)
environmental
format
neat
storage temp.
2-8°C
Quality Level
General description
Glycidamide, an active epoxide metabolite of acrylamide with potential biological activity, can be generated in vivo. Its mutagenic and genotoxic nature is well-known.
Application
Glycidamide may be used as an analytical standard for the determination of the analyte in human and animal biological samples by various chromatography techniques.
Other Notes
2008 年夏天慕尼黑理工大学的研究人员在薯片中检测到了除丙烯酰胺之外的环氧丙酰胺。环氧丙酰胺为丙烯酰胺的代谢物。
signalword
Danger
Hazard Classifications
Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
D S Barber et al.
Journal of chromatography. B, Biomedical sciences and applications, 758(2), 289-293 (2001-08-07)
Acrylamide is a widely used monomer that produces peripheral neuropathy. It is metabolized to the epoxide, glycidamide, which is also considered to be neurotoxic. A new reversed-phase high-performance liquid chromatography (HPLC) method is described that permits simultaneous determination of acrylamide
Franz Ingo Berger et al.
Molecular nutrition & food research, 55(3), 387-399 (2010-10-13)
Acrylamide (AA), classified as a genotoxic carcinogen, is generated by heating foods. We studied whether the food matrix modulates bioavailability and/or biotransformation and investigated kinetics and biological effectiveness of AA in rats. AA was given to the animals at a
Rui-Sheng Wang et al.
Toxicological sciences : an official journal of the Society of Toxicology, 117(1), 72-80 (2010-06-29)
Acrylamide (AA) is an industrial chemical, a by-product of fried starchy foods, and a mutagen and rodent carcinogen. It can also cause damage during spermatogenesis. In this study, we investigated whether AA and its metabolite glycidamide (GA) induce mutagenic effects
Natalia Kotova et al.
Toxicology letters, 207(1), 18-24 (2011-09-01)
Acrylamide (AA) is produced in many types of food products cooked or processed at high temperature. AA is metabolized to the epoxide glycidamide (GA), which can bind to deoxyguanosine and deoxyadenosine in DNA. The GA-derived N7-guanine and N3-adenine adducts are
Anja Olsen et al.
Toxicology, 296(1-3), 67-72 (2012-04-03)
Acrylamide is a probable human carcinogen, with industrial contact, tobacco smoking and foods processed at high temperatures as the main routes of exposure. In animal studies oral intake of acrylamide has been related to cancer development, with indications that the
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