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00881

Supelco

(±)-4-Hydroxypropranolol hydrochloride

analytical standard

别名:

1-[(4-Hydroxy-1-naphthyl)oxy]-3-(isopropylamino)- 2-propanol hydrochloride, 4′-Hydroxypropranolol hydrochloride, 4-{2-Hydroxy-3-[(1-methylethyl)amino]propoxy}-1-naphthalenol hydrochloride

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About This Item

经验公式（希尔记法）:
C16H21NO3·HCl
CAS号:
14133-90-5
分子量:
311.80
Beilstein:
4036845
MDL编号:
MFCD06656370
UNSPSC代码:
41116107
PubChem化学物质编号:
329747156
NACRES:
NA.24

等级

analytical standard

质量水平

100

方案

≥98.5% (AT)
≥98.5% (HPLC)

保质期

limited shelf life, expiry date on the label

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

forensics and toxicology
pharmaceutical (small molecule)

包装形式

neat

储存温度

2-8°C

SMILES字符串

CC(C)NCC(O)COC1=CC=C(O)C2=CC=CC=C21.Cl

InChI

1S/C16H21NO3.ClH/c1-11(2)17-9-12(18)10-20-16-8-7-15(19)13-5-3-4-6-14(13)16;/h3-8,11-12,17-19H,9-10H2,1-2H3;1H

InChI key

ROUJENUXWIFONU-UHFFFAOYSA-N

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储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCL5746
BCCH1537
BCCC6246
BCBV6968

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S Narimatsu et al.
Biological & pharmaceutical bulletin, 24(9), 988-994 (2001-09-18)
Repetitive administration of propranolol (PL) in rats decreases the activities of cytochrome P450 (CYP) 2D enzyme(s) in hepatic microsomes. We examined the properties of 4-hydroxypropranolol (4-OH-PL) as an inactivator of rat liver microsomal CYP2D enzyme(s) using bunitrolol (BTL) 4-hydroxylation and
K Rowland et al.
British journal of clinical pharmacology, 38(1), 9-14 (1994-07-01)
1. The 4-hydroxylation of propranolol by rat and human liver microsomes is associated with formation of a chemically reactive species which binds irreversibly to cytochrome P4502D6 (CYP2D6) destroying its catalytic function. Therefore, the effect of propranolol treatment (80 mg twice
Y Masubuchi et al.
Biochemical pharmacology, 43(4), 757-762 (1992-02-18)
The mechanism of selective inhibition of propranolol hydroxylations after multiple administration of the drug was investigated by metabolic inhibition studies in rat liver microsomes. The time course of irreversible binding of a reactive metabolic intermediate(s) of propranolol to liver microsomal
F Moriya et al.
Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence, 26(5), 360-366 (1991-10-01)
Effect of ethanol administration on blood propranolol concentration (BPC) was investigated with rats. By oral administration of 20 mg/kg propranolol hydrochloride together with 1.5 g/kg of ethanol, it was suggested that there might be an increase in blood 4-hydroxypropranolol concentration
Wenying Jian et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 878(31), 3267-3276 (2010-11-09)
In recent years, increasing emphasis has been placed on quantitative characterization of drug metabolites for better insight into the correlation between metabolite exposure and toxicological observations or pharmacological efficacy. One common strategy for metabolite quantitation is to adopt the stable
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