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Merck
CN

00530580

番泻苷 B

primary reference standard

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关于此项目

经验公式（希尔记法）:
C42H38O20
化学文摘社编号:
128-57-4
分子量:
862.74
UNSPSC Code:
85151701
NACRES:
NA.24
PubChem Substance ID:
329747089
EC Number:
204-895-0
Beilstein/REAXYS Number:
5723747
MDL number:
MFCD00151528

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InChI

1S/C42H38O20/c43-11-23-31(47)35(51)37(53)41(61-23)59-21-5-1-3-15-25(17-7-13(39(55)56)9-19(45)27(17)33(49)29(15)21)26-16-4-2-6-22(60-42-38(54)36(52)32(48)24(12-44)62-42)30(16)34(50)28-18(26)8-14(40(57)58)10-20(28)46/h1-10,23-26,31-32,35-38,41-48,51-54H,11-12H2,(H,55,56)(H,57,58)/t23-,24-,25-,26+,31-,32-,35+,36+,37-,38-,41-,42?/m1/s1

SMILES string

OC[C@H]1O[C@@H](Oc2cccc3[C@@H]([C@H]4c5cccc(O[C@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)c5C(=O)c7c(O)cc(cc47)C(O)=O)c8cc(cc(O)c8C(=O)c23)C(O)=O)[C@H](O)[C@@H](O)[C@@H]1O

InChI key

IPQVTOJGNYVQEO-OVYIKYHGSA-N

grade

primary reference standard

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

HWI

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

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相关类别

General description

Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.

Application

草药产品分析的标准品。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

No data available

flash_point_c

No data available

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
HWI00197-5
HWI00197-3

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Yen-Chun Chen et al.
Life sciences, 84(25-26), 915-922 (2009-04-28)
To address the possibility that sennoside B inhibition of cell proliferation is mediated via interference with platelet-derived growth factor (PDGF) signaling. Human osteosarcoma MG63 cells were treated with PDGF in the presence or absence of sennoside B. Activation of the
Kento Takayama et al.
Chemical & pharmaceutical bulletin, 59(9), 1106-1109 (2011-09-02)
Daiokanzoto (DKT, combination of rhubarb and glycyrrhiza), a Kampo medicine, is clinically effective for constipation. Sennoside A is well known to induce diarrhea. Sennoside A is a prodrug that is transformed into an active metabolite, rheinanthrone, by intestinal bacteria. In
Meng-Ting Wang et al.
European journal of heart failure, 13(11), 1238-1243 (2011-08-02)
Digoxin is an important medication for heart failure (HF) patients and sennosides are widely used to treat constipation. Recently, safety concerns have been raised about a possible interaction between sennosides and digoxin, an issue that has not been studied empirically.
Mitsuharu Matsumoto et al.
PloS one, 7(2), e31700-e31700 (2012-03-03)
While there are a variety of identifiable causes of constipation, even idiopathic constipation has different possible mechanisms. Sennosides, the main laxative constituents of Daio, an ancient Kampo medicine, are prodrugs that are converted to an active principle, rheinanthrone, by intestinal
Acute hemorrhagic colitis following administration of sennosides for colon cleansing.
Burhan Ozdil et al.
The Annals of pharmacotherapy, 44(4), 770-771 (2010-03-25)
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