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Marta Kolodziejczak et al.
ACS chemical neuroscience, 6(7), 1219-1230 (2015-04-11)
Maturation of functional neuronal circuits during central nervous system development relies on sophisticated mechanisms. First, axonal and dendritic growth should reach appropriate targets for correct synapse elaboration. Second, pruning and neuronal death are required to eliminate redundant or inappropriate neuronal
Douglas M McMillan et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(7), 1804-1812 (2015-01-30)
CYP2D metabolically activates codeine to morphine, which is required for codeine analgesia. Permeability across the blood-brain barrier, and active efflux, suggests that initial morphine in the brain after codeine is due to brain CYP2D metabolism. Human CYP2D is higher in
Xuan Zhang et al.
Nanomedicine : nanotechnology, biology, and medicine, 11(6), 1365-1375 (2015-04-19)
Intratumoral injection of ultra-small gold nanoparticles (AuNPs) conjugated to doxorubicin (Au-Dox) is effective against both murine B16 and human SK-MEL-28 tumors in mice. Au-Dox suppresses growth of B16 tumors in immunocompetent mice by >70% for at least 19 days. In
Davide R Ceratti et al.
Advanced materials (Deerfield Beach, Fla.), 27(34), 4958-4962 (2015-07-23)
A new, simple bi-phasic dip-coating method is developed. This method is considered as a great improvement of the technique for research, development and production, since expensive, rare, harmful, or time-evolving solutions can now be easily deposited on large surfaces and
Jeroen Aerts et al.
Brain structure & function, 220(5), 2675-2689 (2014-06-25)
Matrix metalloproteinases (MMPs) are Zn(2+)-dependent endopeptidases considered to be essential for normal brain development and neuroplasticity by modulating extracellular matrix proteins, receptors, adhesion molecules, growth factors and cytoskeletal proteins. Specifically, MMP-3 has recently been implicated in synaptic plasticity, hippocampus-dependent learning
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