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Merck
CN

03-5330

Sigma-Aldrich

γ-丁内酯

SAJ first grade, ≥99.5%

别名:

γ-羟基丁酸内酯, 4-羟基丁酸内酯, GBL

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About This Item

经验公式(希尔记法):
C4H6O2
CAS号:
分子量:
86.09
Beilstein:
105248
MDL编号:
UNSPSC代码:
12352005
PubChem化学物质编号:

等级

SAJ first grade

蒸汽密度

3 (vs air)

蒸汽压

1.5 mmHg ( 20 °C)

检测方案

≥99.5%

自燃温度

851 °F

expl. lim.

16 %

存货情况

available only in Japan

折射率

n20/D 1.436 (lit.)

bp

204-205 °C (lit.)

mp

−45 °C (lit.)

密度

1.12 g/mL at 25 °C (lit.)

SMILES字符串

O=C1CCCO1

InChI

1S/C4H6O2/c5-4-2-1-3-6-4/h1-3H2

InChI key

YEJRWHAVMIAJKC-UHFFFAOYSA-N

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生化/生理作用

γ-羟基丁酸(GHB)前体。 可通过阻断多巴胺能神经元的脉冲流,抑制多巴胺释放。 γ-丁内酯预处理可用于检测自身受体诱导的多巴胺释放。

象形图

CorrosionExclamation mark

警示用语:

Danger

危险声明

危险分类

Acute Tox. 4 Oral - Eye Dam. 1 - STOT SE 3

靶器官

Central nervous system

WGK

WGK 1

闪点(°F)

closed cup

闪点(°C)

closed cup

法规信息

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Michelle Wood et al.
Journal of chromatography. A, 1056(1-2), 83-90 (2004-12-15)
We have developed a rapid method that enables the simultaneous analysis of gamma-hydroxybutyrate (GHB) and its precursors, i.e. gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) in urine. The method comprised a simple dilution of the urine sample, followed by liquid chromatography-tandem mass
Bo Xue et al.
Biochemistry, 52(13), 2359-2370 (2013-03-07)
The in vitro evolution and engineering of quorum-quenching lactonases with enhanced reactivities was achieved using a thermostable GKL enzyme as a template, yielding the E101G/R230C GKL mutant with increased catalytic activity and a broadened substrate range [Chow, J. Y., Xue
Zheng-Yuan Su et al.
Chemical research in toxicology, 26(3), 477-485 (2013-02-28)
Cancer development has been linked to epigenetic modifications of cancer oncogenes and tumor suppressor genes; in advanced metastatic cancers, severe epigenetic modifications are present. We previously demonstrated that the progression of prostate tumors in TRAMP mice is associated with methylation
Axel Bidon-Chanal et al.
European journal of medicinal chemistry, 60, 479-489 (2013-01-29)
Glycogen synthase kinase 3β (GSK-3β) is widely recognised as a relevant player in the pathogenesis of several highly prevalent disorders such as Alzheimer's disease, mood disorders, diabetes and cancer. Therefore, this enzyme constitutes a highly attractive therapeutic target for the
Christian Westendorf et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(10), 3853-3858 (2013-02-23)
The rapid reorganization of the actin cytoskeleton in response to external stimuli is an essential property of many motile eukaryotic cells. Here, we report evidence that the actin machinery of chemotactic Dictyostelium cells operates close to an oscillatory instability. When

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