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描述
N-methyl-N-deacetyl-colchicine
质量水平
无菌性
sterile; 0.2 μm filtered
形式
solution
包装
pkg of 20 mL (10 μg/ml)
制造商/商品名称
Roche
技术
blocking: suitable
杂质
microbial, tested
溶解性
water: miscible
储存温度
2-8°C
SMILES字符串
CN[C@H]1CCc2cc(OC)c(OC)c(OC)c2C3=CC=C(OC)C(=O)C=C13
InChI
1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3/t15-/m0/s1
InChI key
NNJPGOLRFBJNIW-HNNXBMFYSA-N
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一般描述
秋水仙胺也被称为地美辛星。它的通用名称是 N-甲基-N-去乙酰秋水仙碱。秋水仙胺可解聚微管并在中期阻断有丝分裂。
应用
秋水仙碱可抑制有丝分裂纺锤体的形成。它可用于增加染色体分析中中期细胞的百分比。
生化/生理作用
通常在核型分析和细胞周期研究中，其可在细胞周期的特定阶段增加有丝分裂细胞的产量。这可以通过多种方式来实现，其中最流行的是使用细胞周期同步剂，例如地美考辛。地美考辛会将细胞停滞于中期，同时对有丝分裂细胞或经同步的G1和S期细胞中的生化事件无明显影响。经常会用地美可辛处理白细胞以阻止中期细胞。
外形
溶液（10 μg/ml），已通过0.2 μm孔径滤膜过滤。
其他说明
仅用于生命科学研究。不用于诊断操作。
WGK
nwg
闪点(°F)
does not flash
闪点(°C)
does not flash
法规信息
监管及禁止进口产品
Johannes Bloehdorn et al.
Nature communications, 12(1), 5395-5395 (2021-09-15)
Knowledge of the genomic landscape of chronic lymphocytic leukemia (CLL) grows increasingly detailed, providing challenges in contextualizing the accumulated information. To define the underlying networks, we here perform a multi-platform molecular characterization. We identify major subgroups characterized by genomic instability
Naiara Zoccal Saraiva et al.
Cloning and stem cells, 11(1), 141-152 (2009-02-20)
This study aimed to evaluate the effect of demecolcine, a microtubule-depolymerizing agent, on microtubule kinetics; to determine the best concentration of demecolcine as a chemically assisted enucleation agent in metaphase I (MI) and metaphase II (MII) bovine oocytes, and to
Vasiliki Tasiou et al.
PloS one, 10(8), e0134672-e0134672 (2015-08-15)
The human RB1 gene is imprinted due to integration of the PPP1R26P1 pseudogene into intron 2. PPP1R26P1 harbors the gametic differentially methylated region of the RB1 gene, CpG85, which is methylated in the female germ line. The paternally unmethylated CpG85
Candice L Wike et al.
eLife, 5, e11402-e11402 (2016-02-18)
Phosphorylation of histone H3 threonine 118 (H3 T118ph) weakens histone DNA-contacts, disrupting the nucleosome structure. We show that Aurora-A mediated H3 T118ph occurs at pericentromeres and chromosome arms during prophase and is lost upon chromosome alignment. Expression of H3 T118E
Roshan L Shrestha et al.
The Journal of cell biology, 220(4) (2021-02-24)
Chromosomal instability (CIN) is a hallmark of many cancers. Restricting the localization of centromeric histone H3 variant CENP-A to centromeres prevents CIN. CENP-A overexpression (OE) and mislocalization have been observed in cancers and correlate with poor prognosis; however, the molecular
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