推荐产品
质量水平
形式
powder
分子量
Mr 506.2 (ANP-PNP)
Mr 529.9 (AMP-PNP-Li4)
包装
pkg of 25 mg
制造商/商品名称
Roche
SMILES字符串
[Li+].[Li+].[Li+].[Li+].[H]O[H].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)NP([O-])([O-])=O)[C@@H](O)[C@H]3O
InChI
1S/C10H17N6O12P3/c11-8-5-9(13-2-12-8)16(3-14-5)10-7(18)6(17)4(27-10)1-26-31(24,25)28-30(22,23)15-29(19,20)21/h2-4,6-7,10,17-18H,1H2,(H,24,25)(H2,11,12,13)(H4,15,19,20,21,22,23)/t4-,6-,7-,10-/m1/s1
InChI key
PVKSNHVPLWYQGJ-KQYNXXCUSA-N
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一般描述
AMP-PNP(亚胺二磷酸腺苷)是ATP的非水解类似物。它可抑制快速轴突转运,促进膜性细胞器和微管之间的相互作用。
AMP-PNP(亚胺二磷酸腺苷)是腺苷酸环化酶的一种人造底物。腺苷酸环化酶水解亚胺二磷酸腺苷的速度比ATP慢。
应用
AMP-PNP是大多数ATP性依赖系统的竞争性抑制剂。α- 和 β磷原子键水解的良好底物,但耐受性β- 和 γ磷原子键裂解酶。蛇毒磷酸二酯酶和腺苷酸环化酶底物。
AMP-PNP已用于双动力荧光检测。
AMP-PNP已用于双动力荧光检测。
亚胺二磷酸腺苷已用于制备核苷酸溶液,双动力荧光检测结合肌动蛋白制备流动细胞以及级联结合反应。
特点和优势
内容物
88% AMP-PNP(N 端),4.5%锂,5%水
88% AMP-PNP(N 端),4.5%锂,5%水
质量
污染物:≤1.5% Pi,<0.1% ATP (酶法)
储存及稳定性
-15至-25°C储存。(干燥储存!)
其他说明
仅用于生命科学研究。不可用于诊断。
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
High accuracy measurements of nanometer-scale distances between fluorophores at the single-molecule level
bioRxiv, 234740-234740 (2017)
Nature, 317(6032), 73-75 (1985-09-05)
Identification of the ATPase involved in fast axonal transport of membranous organelles has proven difficult. Myosin and dynein, other ATPases known to be involved in cell motility, have properties that are inconsistent with the established properties of fast axonal transport
Nucleotide dependence of the dimerization of ATP binding cassette nucleotide binding domains
Biochemical and Biophysical Research Communications, 480(2), 268-272 (2016)
Structure (London, England : 1993), 28(1), 96-104 (2019-11-20)
Yeast Tel1 and its highly conserved human ortholog ataxia-telangiectasia mutated (ATM) are large protein kinases central to the maintenance of genome integrity. Mutations in ATM are found in ataxia-telangiectasia (A-T) patients and ATM is one of the most frequently mutated
Nature communications, 12(1), 828-828 (2021-02-07)
The co-chaperone p23 is a central part of the Hsp90 machinery. It stabilizes the closed conformation of Hsp90, inhibits its ATPase and is important for client maturation. Yet, how this is achieved has remained enigmatic. Here, we show that a
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