生物来源
mouse
质量水平
抗体形式
purified antibody
抗体产品类型
primary antibodies
克隆
1F3.9, monoclonal
形式
liquid
不包含
preservative
种属反应性
human, rat, mouse
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
avoid repeated freeze/thaw cycles
同位素/亚型
IgG
运输
wet ice
储存温度
−70°C
靶向翻译后修饰
unmodified
基因信息
human ... PPARGC1A(10891)
一般描述
Protein G purified mouse monoclonal antibody. Recognizes the ~113 kDa PGC-1α protein.
Recognizes the ~113 kDa PGC-1α protein in COS cells.
This Anti-PGC-1α Mouse mAb (1F3.9) is validated for use in Immunoblotting, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation for the detection of PGC-1α.
免疫原
A recombinant protein consisting of amino acids 1-120 of mouse PGC-1α
应用
Immunoblotting (1 g/ml)
Immunocytochemistry (5-10 g/ml)
Immunohistochemistry (5-10 g/ml)
Immunoprecipitation (1:100)
警告
Toxicity: Regulatory Review (Z)
外形
In 50 mM PBS
分析说明
Positive Control
Brown adipose tissue from mice exposed to cold
Brown adipose tissue from mice exposed to cold
其他说明
Chang, J.S., et al. 2010. J. Biol. Chem.285, 18039.
Zhang, Y. et al. 2009. J. Biol. Chem.284, 32813.
Lai, L., et al. 2008. Genes Dev.14, 1948.
Rodgers, J.T., et al. 2008. FEBS Lett.582, 46.
Mazzucotelli, A., et al. 2007. Diabetes10, 2467.
Nemoto, S., et al. 2005. J. Biol. Chem.16, 16456.
Zhang, Y. et al. 2009. J. Biol. Chem.284, 32813.
Lai, L., et al. 2008. Genes Dev.14, 1948.
Rodgers, J.T., et al. 2008. FEBS Lett.582, 46.
Mazzucotelli, A., et al. 2007. Diabetes10, 2467.
Nemoto, S., et al. 2005. J. Biol. Chem.16, 16456.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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WGK
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Dorothy E Vatner et al.
Aging cell, 17(4), e12751-e12751 (2018-04-15)
Disruption of the regulator for G protein signaling 14 (RGS14) knockout (KO) in mice extends their lifespan and has multiple beneficial effects related to healthful aging, that is, protection from obesity, as reflected by reduced white adipose tissue, protection against
Seong-Hoon Yun et al.
Anticancer research, 40(2), 653-664 (2020-02-06)
Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is a master regulator of mitochondrial biogenesis and metabolism. We investigated the effect of PGC-1α knockdown in the human colorectal cancer cell line SW620, which highly expresses PGC-1α. We established the PGC-1α shRNA-silenced
Kin H Lau et al.
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Brown adipose tissue (BAT) has the ability to burn calories as heat. Utilizing BAT thermogenesis is thus an attractive way to combat obesity. However, the transcriptional network resulting in the lipid synthesis to oxidation shift during thermogenesis is not completely
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Hyperglycemia affects over 400 million individuals worldwide. The detrimental health effects are well studied at the tissue level, but the in vivo effects at the organelle level are poorly understood. To establish such an in vivo model, we used mice lacking TXNIP
Sajedah M Hindi et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(3), 1398-1411 (2013-12-12)
Skeletal muscle wasting attributed to inactivity has significant adverse functional consequences. Accumulating evidence suggests that peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) and TNF-like weak inducer of apoptosis (TWEAK)-Fn14 system are key regulators of skeletal muscle mass in various catabolic
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