OCUG-1 Human Gallbladder Carcinoma Cell Line

The OCUG-1 human gallbladder carcinoma cell line has been used to study hapatobiliary cancer in genome-wide mutation and expression studies.

SCC642 (OCUG-1), the human gallbladder carcinoma cell line, was isolated from the peritoneal effusion of a Japanese male patient with malignant gallbladder carcinoma. Although the primary tumor was diagnosed as a poorly differentiated adenocarcinoma, and the reconstituted tumors in nude mice also exhibited the same histologic characteristics, the OCUG-1 cells were found to abundantly express the Tumor-Associated Antigen 4 (TA-4), which had been identified as a serum marker for cervical squamous cell carcinoma. This led Yamada et al. to propose that OCUG-1 might be a transitional form between adenocarcinoma and squamous cell carcinoma and represented a useful model system for investigating the squamatization processes. Subsequently, one of the major components of TA-4, the Squamous Cell Carcinoma Antigen 1 (SCCA1, also known as SERPINB3, the Serine Protease Inhibitor Clade B Member 3), was shown to induce the squamatization and disease progression in pancreatic cancer by the inhibition of the degradation of the MYC proto-oncogene.

As one of the relatively few available gallbladder cancer cell lines, OCUG-1 has been examined as a representative hapatobiliary cancer in genome-wide mutation and expression studies. In one such study, Scherer et al. noted that the expression profile of the known primary gallbladder tumor markers is not commonly shared by the gallbladder cancer cell lines and suggested that investigators choose their cellular platforms based not only on the tissue origin of the tumors but also on the driver gene expression patterns underlying the specific mechanisms of tumorigenesis.

Source
SCC642 cell line was isolated from the peritoneal effusion of a 43 year old Japanese male patient with malignant gallbladder carcinoma.

References
1. Yamada N, Chung Y, Ohtani H, Ikeda T, Onoda N, Sawada T, Nishiguchi Y, Hasuma T, Sowa M. Establishment and characterization of a new human gallbladder carcinoma cell line (OCUG-1) producing TA-4. Int J Oncol. 1997 Jun;10(6):1251-5.

OCUG-1 cells should be stored in liquid nitrogen. The cells can be cultured for at least 10 passages without significantly affecting cell marker expression and function.

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