sBT-RMS Spontaneous Brain-tropic RET Melanoma-sorted Mouse Cell Line

sBT-RMS cells should be stored in liquid nitrogen until use. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.

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SCC463, the sBT-RMS spontaneous brain-tropic RET melanoma-sorted mouse cell line, demonstrates more aggressive brain metastasis than the parental RMS cell line, and exhibits higher organ specificity.

SCC463 is a derivative of the SCC462 cell line. Parental SCC462 were isolated from a spontaneously occurring skin tumor in RET transgenic mice. The sBT-RMS cell line was isolated from the brain metastasis following the subdermal injection of RMS cells.5 sBT-RMS cells are more aggressive in brain metastasis than the parental RMS line and exhibited higher organ-specificity.

The RET oncogene was originally created by an accidental in vivo recombination of two human genes, RET and RFP (the RET-finger protein, known today as TRIM27), during a transformation of NIH3T3 cells with human lymphoma DNA (Takahashi 1985). The founder R

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