SF188 Human Glioblastoma Cell Line

Glioblastoma multiforme is the most common and malignant primary brain tumor, with a high recurrence rate and a five-year survival rate of less than 5% (1). Glioblastomas represent approximately 10% of brain tumors in children and pediatric forms often have characteristics distinct from adult forms (2). Glioblastomas are the most aggressive form of cancer, highlighting the importance of relevant human patient-derived cell models for advancing research into characteristics and treatment of this disease.

SF188 is a patient-derived glioblastoma cell line originating from a temporal lobe tumor (3). SF188 cells do not express the glial markers GFAP or glutamine synthetase but are positive for laminin and fibronectin expression in early passages, suggestive of proliferative or transformed mesenchymal cells of glioblastoma (3). SF188 cells exhibit hypertriploidy and epithelial morphology in culture and are non-tumorigenic in athymic mice (3). The SF188 cell line possesses genetic amplification of the proliferative factor c-myc (4).

<bold>Source:</bold>
The SF188 glioblastoma cell line was derived from the left temporal lobe tumor of an 8-year-old male patient (3).

Research Category:
Cancer

Human, Cancer Cells

&ge;1X10⁶ cells/vial

Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.

This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.