YUMM 1.1 Mouse Melanoma Cell Line

YUMM1.1 cells are syngeneic with the immunocompetent C57BL/6 mouse background and retain genetic markers of the Braf/Pten mouse models, characterized by activation of Braf and inactivation of Pten and Cdkn2a.

The YUMM cell lines recapitulate genetic drivers found in many human melanomas. YUMM1.1 is driven by Braf activation, Pten/Cdkn2a inactivation, and is highly tumorigenic in vivo.

The promise of immune-based therapies in cancer and recent progress in successful application of these approaches has confirmed the utility of immunocompetent models for evaluation of the immune system response to cancer cells. Genetically engineered mou

YUMM1.1 cells should be stored in liquid nitrogen until use. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.

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Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.