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一般描述
MB49细胞来自C57BL/Icrf-a’小鼠膀胱上皮细胞，在长期原代培养的第二天经化学致癌物7, 12-二甲苯[a]蒽（DMBA）单独处理24小时后转化。 经证实，移植到同基因鼠体内的转化细胞可诱发癌症。 而对父系起源，核型分析表明Y染色体在所分析的细胞中会100%丢失。 这种异常是人类膀胱癌的常见早期事件。 最近的一项研究表明，MB49细胞再现了膀胱肿瘤生长中性别差异的关键特征。 MB49植入小鼠后，雄性小鼠的肿瘤明显大于雌性小鼠。 在双氢睾酮的作用下，MB49细胞呈剂量依赖性增殖增强。 相反，MB49细胞对妊娠激素、人绒毛膜促性腺激素(hCG)无反应。MB49细胞表现为MHC-I类和II类分子的低表达或不表达。 然而，IFN-暴露后，MHC I类和II类表达显著上调。
质量
• 每小瓶含有≥ 1X106个活细胞。
• Charles River动物诊断服务通过小鼠Essential CLEAR小组对细胞进行传染病检测，结果为阴性。
• 通过Charles River动物诊断服务的污染透明小组评估，证实细胞为小鼠来源，对大鼠、中国仓鼠、金色黄叙利亚仓鼠、人和非人灵长类动物（NHP）的种间污染物呈阴性。
• 细胞对支原体污染呈阴性
• Charles River动物诊断服务通过小鼠Essential CLEAR小组对细胞进行传染病检测，结果为阴性。
• 通过Charles River动物诊断服务的污染透明小组评估，证实细胞为小鼠来源，对大鼠、中国仓鼠、金色黄叙利亚仓鼠、人和非人灵长类动物（NHP）的种间污染物呈阴性。
• 细胞对支原体污染呈阴性
其他说明
根据产品文件中详述的“学术使用协议”的条款，本产品预期仅用于销售和销售给学术机构，以供内部学术研究使用。有关任何其他用途的信息，请联系licensing@emdmillipore.com。
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
I C Summerhayes et al.
Journal of the National Cancer Institute, 62(4), 1017-1023 (1979-04-01)
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