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安全信息

RPTMAG-86K

Millipore

MILLIPLEX® 大鼠垂体磁珠面板-内分泌多重检测

The analytes available for this multiplex kit are: ACTH, BDNF, FSH, GH, LH, Prolactin, TSH.

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About This Item

UNSPSC代码:
12161503
eCl@ss:
32161000
NACRES:
NA.84

质量水平

200

种属反应性

rat

制造商/商品名称

Milliplex®

assay range

accuracy: 75%
(GH)
accuracy: 88%
(ACTH)
accuracy: 89%
(LH)
accuracy: 90%
(TSH)
sensitivity: 0.38 pg/mL
(BDNF)
sensitivity: 0.87 pg/mL
(TSH)
sensitivity: 1.95 pg/mL
(ACTH)
sensitivity: 3.28 pg/mL
(LH)
sensitivity: 4.64 pg/mL
(Prolactin)
sensitivity: 6.50 pg/mL
(GH)
sensitivity: 7.62 pg/mL
(FSH)
standard curve range: 16-50,000 pg/mL
(GH, Prolactin)
standard curve range: 3.2-10,000 pg/mL
(ACTH, BDNF, LH, TSH)
standard curve range: 32-100,000 pg/mL
(FSH)
inter-assay cv: <20%
intra-assay cv: <10%

技术

multiplexing: suitable

检测方法

fluorometric (Luminex xMAP)

运输

wet ice

相关类别

一般描述

由于它控制许多其他内分泌腺，因此被称为主腺，垂体分泌许多关键激素，这些激素在代谢、生长和繁殖的调节中起重要作用。垂体激素负责刺激肾上腺（ACTH），甲状腺（TSH），卵巢和睾丸（FSH，LH）和母乳产生（催乳素），以及血压和肾脏排泄的水量。通过与垂体的联系，下丘脑通过检测激素水平来调节内分泌功能。脑源性神经营养因子（BDNF）是神经营养因子NGF家族的成员，是特定神经元亚群分化和存活所必需的。

MILLIPLEX® 大鼠垂体面板是一种7重试剂盒，用于同时定量大鼠血清或血浆样本、大鼠组织提取物或细胞/组织培养上清液样本中的以下任何或所有分析物：生长激素（GH）、促甲状腺激素（TSH）、促肾上腺皮质激素（ACTH）、促黄体生成激素（LH）、催乳素、促卵泡激素（FSH）和脑源性神经营养因子（BDNF）。该试剂盒采用96孔板，包含冻干标准混合物、两个内部检测质控品，最多可测量38份样本，一式两份。

Luminex® xMAP®平台使用磁珠免疫分析格式，以实现理想的速度和灵敏度，同时定量多种分析物，从而显著提高生产力，同时节省有价值的样品量。

面板类型：内分泌

应用

  • 分析物：促肾上腺皮质激素（ACTH）、脑源性神经营养因子（BDNF）、促卵泡激素（FSH）、生长激素（GH）、促黄体激素（LH）、催乳素、促甲状腺激素（TSH）
  • 推荐样品类型：大鼠血清、血浆、细胞/组织培养物上清液或裂解物
  • 推荐样品稀释度：每孔25 μL 1:3稀释的血清或血浆；细胞/组织培养样品可能需要在适当的对照培养基中稀释。
  • 分析运行时间：在2-8℃下过夜（16-18小时）
  • 研究类别：内分泌
  • 研究子类别：代谢

特点和优势

通过在此面板中选择可用的分析物来设计多重试剂盒。

法律信息

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

象形图

Skull and crossbonesEnvironment
GHS06,GHS09

警示用语：

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Sens. 1

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

法规信息

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Vivi F H Jensen et al.
Scientific reports, 10(1), 5609-5609 (2020-03-30)
Maternal hypoglycaemia throughout gestation until gestation day (GD)20 delays foetal growth and skeletal development. While partially prevented by return to normoglycaemia after completed organogenesis (GD17), underlying mechanisms are not fully understood. Here, we investigated the pathogenesis of these changes and
Global but not gonadotrope-specific disruption of Bmal1 abolishes the luteinizing hormone surge without affecting ovulation.
Chu, A; Zhu, L; Blum, ID; Mai, O; Leliavski, A; Fahrenkrug, J; Oster, H; Boehm, U; Storch, KF
Endocrinology null
Mirjam Kowallick et al.
Frontiers in pediatrics, 9, 723928-723928 (2021-11-23)
Introduction: High oxygen concentrations have been identified as one factor contributing to the pathogenesis of the retinopathia of prematurity, chronic lung disease of the preterm infant and preterm brain injury. Preterm infants also show short- and long-term alterations of the
Jennifer M Rojas et al.
Toxicologic pathology, 46(7), 777-798 (2018-10-23)
The obese rodent serves as an indispensable tool for proof-of-concept efficacy and mode-of-action pharmacology studies. Yet the utility of this disease model as an adjunct to the conventional healthy animal in the nonclinical safety evaluation of anti-obesity pharmacotherapies has not
Renee N Sadowski et al.
Neurotoxicology and teratology, 42, 17-24 (2014-01-21)
Previous work has shown that exposure to bisphenol A (BPA) can affect anxiety behavior. However, no studies have examined whether administration of this endocrine disruptor during the perinatal period has the potential to induce alterations in cognitive behavior in both
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