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安全信息

RMHMAG-84K

Millipore

MILLIPLEX® 大鼠代谢激素磁珠面板-代谢多重检测

The analytes available for this multiplex kit are: Amylin (Active), C-Peptide 2, Ghrelin (Active), GIP (Total), GLP-1 (Active), Glucagon, IL-6, Insulin, Leptin, MCP-1, PP, PYY, TNF-α.

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About This Item

UNSPSC代码:
12161503
eCl@ss:
32161000
NACRES:
NA.84

质量水平

200

种属反应性

rat

制造商/商品名称

Milliplex®

assay range

accuracy: 103%
(Amylin (Active))
accuracy: 96%
(GLP-1 (Active))
accuracy: 96%
(IL-6)
accuracy: 96%
(MCP-1)
accuracy: 98%
(TNFα)
accuracy: 99%
(C-Peptide 2)
accuracy: 99%
(Insulin)
sensitivity: 1-62 pg/mL
standard curve range: 14-10,000 pg/mL
(Glucagon & TNFα)
standard curve range: 2.7-2,000 pg/mL
(GIP (Total))
standard curve range: 41-30,000 pg/mL
(Amylin (Active) & GLP-1 (Active))
standard curve range: 69-50,000 pg/mL
(C-Peptide 2, IL-6, Insulin, Leptin & MCP-1)
standard curve range: 7-5,000 pg/mL
(Ghrelin (Active), PP & PYY (Total))

技术

multiplexing: suitable

检测方法

fluorometric (Luminex xMAP)

运输

wet ice

一般描述

代谢综合症是一系列疾病，包括血压升高，胰岛素水平升高，胆固醇水平异常和腰部脂肪过多。代谢综合征的关键特征包括胰岛素抗性，葡萄糖耐受不良，高血压，血脂异常和中枢性肥胖。

MILLIPLEX® 大鼠代谢面板是一种13重试剂盒，用于同时定量组织/细胞裂解物和培养上清液样品以及血清或血浆样品中的以下任何或所有分析物：Amylin（活性），C肽2，活性胃饥饿素，GIP，GLP-1，胰高血糖素，IL-6，胰岛素，瘦素，MCP-1，PP，PYY和TNFα。该试剂盒采用96孔板，包含冻干标准混合物、两个内部检测质控品，最多可测量38份样本，一式两份。

Luminex® xMAP®平台使用磁珠免疫分析格式，以实现理想的速度和灵敏度，同时定量多种分析物，从而显著提高生产力，同时节省有价值的样品量。

面板类型：代谢

特异性

交叉反应性
与其他测试的激素无明显交叉反应。

应用

  • 分析物：Amylin（活性），C肽2，胃饥饿素（活性），GIP（总计），GLP-1（活性），胰高血糖素，IL-6，胰岛素，瘦素，MCP-1（CCL2），胰多肽（PP），PYY（总计）和TNFα
  • 推荐的样品类型：大鼠血清、血浆、细胞/组织培养物上清液和裂解物。
  • 注：对于特定的分析物，应在采血后添加蛋白酶抑制剂：GLP-1的DPPIV（活性）；胰岛淀粉样多肽蛋白酶抑制剂混合物（活性）；胰高血糖素用抑肽酶；胃饥饿素的丝氨酸蛋白酶抑制剂（活性）
  • 建议的样品稀释度：每孔25 μL未稀释的血清或血浆；细胞/组织培养样品可能需要在适当的对照培养基中稀释。
  • 分析运行时间：在2-8℃下过夜（18-20小时）
  • 研究类别：代谢
  • 研究类别：代谢紊乱、肥胖、内分泌

特点和优势

通过在此面板中选择可用的分析物来设计多重试剂盒。

法律信息

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

免责声明

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

象形图

Skull and crossbonesEnvironment
GHS06,GHS09

警示用语：

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Sens. 1

补充剂危害

EUH032

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

法规信息

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Carolina Soares Moura et al.
Food & nutrition research, 61(1), 1290740-1290740 (2017-03-23)
Background: Several physiologically beneficial effects of consuming a whey protein hydrolysate (WPH) have been attributed to the greater availability of bioactive peptides. Aims: The aim was to investigate the effect of four branched-chain amino acid- (BCAA-)containing dipeptides, present in WPH
Atanu Pal et al.
Diabetes, 64(6), 1941-1950 (2015-01-13)
The antidiabetes effects of Roux-en-Y gastric bypass (RYGB) are well-known, but the underlying mechanisms remain unclear. Isolating the proximal small intestine, and in particular its luminal glucose sensors, from the nutrient stream has been proposed as a critical change, but
Maritza J Romero et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(7), 1895-1900 (2016-02-03)
Dyslipidemia associated with triglyceride-rich lipoproteins (TRLs) represents an important residual risk factor for cardiovascular and chronic kidney disease in patients with type 1 diabetes (T1D). Levels of growth hormone (GH) are elevated in T1D, which aggravates both hyperglycemia and dyslipidemia.
Chronic coffee consumption in the diet-induced obese rat: impact on gut microbiota and serum metabolomics.
Cowan, TE; Palmnas, MS; Yang, J; Bomhof, MR; Ardell, KL; Reimer, RA; Vogel, HJ; Shearer, J
The Journal of Nutritional Biochemistry null
Laelie A Snook et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 309(3), R295-R303 (2015-06-05)
Several gastrointestinal proteins have been identified to have insulinotropic effects, including glucose-dependent insulinotropic polypeptide (GIP); however, the direct effects of incretins on skeletal muscle glucose transport remain largely unknown. Therefore, the purpose of the current study was to examine the
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