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Merck
CN

OP44

APC (Ab-1)小鼠单克隆抗体(FE9)

liquid, clone FE9, Calbiochem®

别名:

抗-腺瘤性息肉病性大肠埃希菌

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关于此项目

NACRES:
NA.43
UNSPSC Code:
12352203
Clone:
FE9, monoclonal
Species reactivity:
rat, human, mouse
Application:
Citations:
23

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产品名称

APC (Ab-1)小鼠单克隆抗体(FE9), liquid, clone FE9, Calbiochem®

biological source

mouse

antibody form

purified antibody

antibody product type

primary antibodies

clone

FE9, monoclonal

form

liquid

contains

≤0.1% sodium azide as preservative

species reactivity

rat, human, mouse

manufacturer/tradename

Calbiochem®

storage condition

do not freeze

dilution

(Immunoblotting (1 µg/mL))

isotype

IgG1

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... APC(324)

相关类别

Analysis Note

阳性对照
HCT116细胞用于p300，SW480细胞用于截短APC（p147）

Application

免疫印迹（1 µg/ml，参见注释）

Disclaimer

毒性：标准处理（A）

General description

可识别HCT116细胞中的全长APC（p300）和SW480细胞中的截短APC（p147）。
  • 抗体靶基因符号：APC
  • 目标同义词：AI047805，Apc7，AU020952，AW124434，BTPS2，DP2，DP2.5，DP3，家族性腺瘤性息肉病，FAP，GS，Min，RATAPC
  • Entrez基因名称：腺瘤性息肉病
  • Hu Entrez ID：324（有关抗体：OP80，ST1150，OP62，OP47L）
  • Mu Entrez ID：11789
  • 大鼠Entrez ID：24205
    • 抗APC（Ab-1），小鼠单克隆，克隆FE9，可识别HCT116细胞中的全长APC（p300）和SW480细胞中的截短APC（p147）。它已被验证可用于蛋白质印迹法。
    蛋白G纯化小鼠单克隆抗体是通过用指定的免疫原免疫小鼠并将脾细胞与SP40细胞融合而产生的。可识别~300 kDa APC蛋白以及多种截短形式。

    Immunogen

    一种与APC N端35个氨基酸对应的合成肽

    Other Notes

    Koetsier, P. A., et al. 1993.BioTechniques15, 258.
    Smith, K. J., et al. 1993.Proc.Natl.Acad.Sci., USA90, 2846.
    Su, L.-K., et al. 1993.Can.Res.53, 2728.
    Boynton, R. F., et al. 1992.Proc.Natl.Acad.Sci. USA89, 3385.
    D′Amico, D., et al. 1992.Cancer Res.52, 1996.
    Fearon, E. R., and Jones, P. A., 1992.FASEB J.6, 2783.
    Miyoshi, Y., et al. 1992.Proc.Natl.Acad.Sci. USA89, 4452.
    Powell, S. M., et al. 1992.Nature359, 235.
    Groden, J., et al. 1991.Cell66, 589.
    Kinzler, K. W., et al. 1991.Science253, 661.
    Nishisho, I., et al. 1991.Science253, 665.

    Packaging

    请参考特定浓度批号的标签。

    Physical form

    溶于50 mM磷酸钠缓冲液（pH 7.5），含0.2％明胶。

    Legal Information

    CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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    存储类别

    11 - Combustible Solids

    wgk

    WGK 1

    flash_point_f

    Not applicable

    flash_point_c

    Not applicable

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    Claudia Gaspar et al.
    PLoS genetics, 5(7), e1000547-e1000547 (2009-07-07)
    Germline mutations in the adenomatous polyposis coli (APC) gene are responsible for familial adenomatous polyposis (FAP), an autosomal dominant hereditary predisposition to the development of multiple colorectal adenomas and of a broad spectrum of extra-intestinal tumors. Moreover, somatic APC mutations
    Nathaniel S Rial et al.
    International journal of cancer, 124(10), 2270-2280 (2009-01-29)
    Elevated deoxycholic acid (DCA), mutations in the adenomatous polyposis coli (APC) gene and chronic inflammation are associated with increased risk of colorectal cancer. APC status was manipulated to determine whether DCA mediates inflammatory molecules in normal or initiated colonic mucosa.
    Jason L Larabee et al.
    The Journal of biological chemistry, 286(22), 19364-19372 (2011-04-14)
    The production of cAMP from Bacillus anthracis edema toxin (ET) activates gene expression in macrophages through a complex array of signaling pathways, most of which remain poorly defined. In this study, the tumor suppressor protein adenomatous polyposis coli (APC) was
    Dipon Das et al.
    DNA repair, 24, 15-25 (2014-12-03)
    Colorectal cancer (CRC) patients with APC mutations do not benefit from 5-FU therapy. It was reported that APC physically interacts with POLβ and FEN1, thus blocking LP-BER via APC's DNA repair inhibitory (DRI) domain in vitro. The aim of this
    Hideaki Toki et al.
    Cancer science, 104(7), 937-944 (2013-04-05)
    Mutant mouse models are indispensable tools for clarifying the functions of genes and elucidating the underlying pathogenic mechanisms of human diseases. We carried out large-scale mutagenesis using the chemical mutagen N-ethyl-N-nitrosourea. One specific aim of our mutagenesis project was to
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