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Merck
CN
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NXF-20

Millipore

Natrix® Q Process 150

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别名:
Natrix® Q膜吸附器
UNSPSC代码:
41115711
eCl@ss:
32011308

ligand

quaternary amine

质量水平

400

描述

Natrix® Q Process 150

产品线

Natrix®

参数

0.6-3 L/min flow rate

床高度

0.5 mm

柱床体积

115 mL

基质活性基团

Macroporous polymer

孔径

0.4 μm pore size

容量

23 g binding capacity (BSA)(per device

per device)

分离技术

strong anion exchange

运输

ambient

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相关类别

一般描述

Natrix®层析膜采用革命性的三维大孔水凝胶结构，提供了高密度的吸附位点和快速传质，其吸附能力超过了树脂填料柱，兼具传统膜吸附剂常见的高流速。这种性能与一次性、即插即用设备的速度的组合，可实现低风险、可放大的高效生物分子纯化解决方案。

Natrix® Q层析膜是一种高产率强阴离子交换膜，专为生物分子纯化而设计。独有的 Natrix® Q层析膜是是一种多孔的聚丙烯酰胺水凝胶，含有高密度的悬垂季铵（Q）结合基团，该基团可在惰性的大孔膜骨架中直接聚合。互连的孔结构和高功能团密度使层析膜兼具高流速和通量以及极高的负载量，同时在多种缓冲液条件下均可维持良好的杂质去除率。Natrix® Q 层析膜设计可提升生产率、灵活性、工艺稳健性和经济性，适用于任意生物工艺设计。atrix® Q Process 150是专为大规模临床和商业制造而设计的工艺放大设备。

抗体标称纯化容量：1150 g
膜配置：折叠膜

单件装
强阴离子交换层析膜设计，可纯化包含高密度季胺配体的生物分子，在高负载下实现高流速和高通量，同时保持出色的杂质去除率

特点和优势

Natrix® Q 膜吸附剂为用户提供了：

  • 高密度季胺结合位点，可实现快速传质
  • 即使在快速流速下也具有高吸附容量
  • 性能与一次性、即插即用设备的速度相结合，可实现低风险、可放大的高效生物分子纯化解决方案。

包装

双层包装

法律信息

NATRIFLO is a trademark of Merck KGaA, Darmstadt, Germany
NATRIX is a registered trademark of Merck KGaA, Darmstadt, Germany

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Mochao Zhao et al.
Vaccine, 37(36), 5491-5503 (2018-04-09)
Affinity chromatography is among the most powerful separation techniques, achieving the finest separation with high yields even in the most challenging feed streams. Incorporating affinity chromatography in vaccine purification has long been attempted by researchers to improve unit yield and
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The current processing paradigm of large manufacturing facilities dedicated to single product production is no longer an effective approach for best manufacturing practices. Increasing competition for new indications and the launch of biosimilars for the monoclonal antibody market have put
Ying Hou et al.
Biotechnology progress, 31(4), 974-982 (2015-05-29)
Protein A chromatography is widely employed for the capture and purification of monoclonal antibodies (mAbs). Because of the high cost of protein A resins, there is a significant economic driving force to seek new downstream processing strategies. Membrane chromatography has

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