产品名称
MILLIPLEX® Mouse Myokine Panel, Configurable Mouse Myokine 12-Plex Panel
species reactivity
mouse
manufacturer/tradename
Milliplex®
Quality Level
packaging
1 ea of
assay range
accuracy: 3-40,000 pg/mL
(Osteocrin)
standard curve range: 0.6-9,000 pg/mL
(BDNF)
standard curve range: 128-2,000,000 pg/mL
(Osteonectin (SPARC))
standard curve range: 16-250,000 pg/mL
(Oncostatin M)
standard curve range: 22-350,000 pg/mL
(EPO)
standard curve range: 256-4,000,000 pg/mL
(Myostatin)
standard curve range: 26-400,000 pg/mL
(26Irisin)
standard curve range: 3-40,000 pg/mL
(LIF)
standard curve range: 3-40,000 pg/mL
(Osteocrin/Musclin (OSTN))
standard curve range: 48-750,000 pg/mL
(IL-15)
standard curve range: 5-75,000 pg/mL
(FGF21)
standard curve range: 9-140,000 pg/mL
(IL-6)
inter-assay cv: <15%
intra-assay cv: <10%
technique(s)
multiplexing: suitable
detection method
fluorometric (Luminex® xMAP® technology)
shipped in
wet ice
storage temp.
2-8°C
Legal Information
Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp
General description
Skeletal muscle functions as an endocrine organ by secreting myokines—proteins that regulate muscle growth, metabolism, and inter-organ communication. This panel—BDNF, Erythropoietin (EPO), FGF-21, Follistatin-like Protein 1 (FSTL1), IL-6, IL-15, Irisin, LIF, Myostatin/GDF8, Oncostatin M (OSM), Osteocrin (OSTN)/Musclin, and Osteonectin/SPARC—captures key indicators of muscle activity, inflammation, and metabolic regulation. The MILLIPLEX® Mouse Myokine Panel enables multiplexed quantification of these biomarkers in mouse serum or plasma, supporting research in exercise physiology, metabolic disease, and muscle biology.
Application
MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 12 analytes in mouse serum, plasma, or cell culture supernatants.
Analytes Included: Brain Derived Neurotrophic Factor (BDNF), Erythropoietin (EPO), Fibroblast Growth Factor 21 (FGF-21), Follistatin-like Protein 1 (FSTL1), IL-6, IL-15, Irisin, Leukemia Inhibitory Factor (LIF), Myostatin (MSTN/GDF8), Oncostatin M (OSM), Osteocrin (OSTN/Musclin), Osteonectin (SPARC) Note: Substantial amounts of BDNF are stored in circulating platelets and subsequently released upon platelet activation. Therefore, platelet-poor plasma is critical to ensure accurate measurement of circulating levels of BDNF. Erythropoeitin (EPO) is for tissue culture samples only and cannot be combined with other analytes in this panel when measuring serum or plasma.
Assay Characteristics: Refer to assay protocol for details on cross-reactivity, sensitivity, precision, and accuracy.
Analytes Included: Brain Derived Neurotrophic Factor (BDNF), Erythropoietin (EPO), Fibroblast Growth Factor 21 (FGF-21), Follistatin-like Protein 1 (FSTL1), IL-6, IL-15, Irisin, Leukemia Inhibitory Factor (LIF), Myostatin (MSTN/GDF8), Oncostatin M (OSM), Osteocrin (OSTN/Musclin), Osteonectin (SPARC) Note: Substantial amounts of BDNF are stored in circulating platelets and subsequently released upon platelet activation. Therefore, platelet-poor plasma is critical to ensure accurate measurement of circulating levels of BDNF. Erythropoeitin (EPO) is for tissue culture samples only and cannot be combined with other analytes in this panel when measuring serum or plasma.
Assay Characteristics: Refer to assay protocol for details on cross-reactivity, sensitivity, precision, and accuracy.
Disclaimer
For research use only. Not for use in diagnostic procedures.
Label License/Sticker for Assay Product:
By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.
Label License/Sticker for Assay Product:
By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.
Features and Benefits
Features:
- Targets myokines involved in muscle growth, metabolism, inflammation, and inter-organ communication
- Includes 12 analytes relevant to skeletal muscle physiology and systemic metabolic regulation
- Multiplex format enables simultaneous detection from minimal sample volume
- Compatible with mouse serum, plasma, and cell/tissue culture supernatants
- Designed for research in exercise physiology, metabolic disorders, and muscle regeneration
- Provides a comprehensive profile of myokines for studying muscle-derived signaling
- Supports investigation of exercise-induced metabolic and immune responses
- Facilitates evaluation of therapeutic interventions in obesity, diabetes, and sarcopenia
- Enables high-throughput analysis with reduced sample and reagent use
- Delivers reproducible, sensitive results for preclinical and translational research
signalword
Danger
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2
target_organs
Respiratory Tract
wgk
WGK 3
法规信息
新产品
此项目有
Sofia Garcia et al.
Aging cell, 17(2) (2018-02-11)
PGC-1α is a transcriptional co-activator known as the master regulator of mitochondrial biogenesis. Its control of metabolism has been suggested to exert critical influence in the aging process. We have aged mice overexpressing PGC-1α in skeletal muscle to determine whether
Edward O List et al.
Endocrinology, 160(1), 68-80 (2018-11-22)
Global GH receptor-null or knockout (GHRKO) mice have been extensively studied owing to their unique phenotype (dwarf and obese but remarkably insulin sensitive and long-lived). To better understand the influence of adipose tissue (AT) on the GHRKO phenotype, we previously
Lars Karlsson et al.
Molecular neurobiology, 58(4), 1465-1481 (2020-11-18)
Physical exercise can improve age-dependent decline in cognition, which in rodent is partly mediated by restoration of an age-dependent decline in neurogenesis. Exercise-inducible myokines in the circulation present a link in muscle-brain crosstalk. The transcription factor PGC-1α regulates the release
Susana Peralta et al.
Journal of cell science, 131(13) (2018-06-15)
Mutations in the mitochondrial inner membrane ATPase ATAD3A result in neurological syndromes in humans. In mice, the ubiquitous disruption of Atad3 (also known as Atad3a) was embryonic lethal, but a skeletal muscle-specific conditional knockout (KO) was viable. At birth, ATAD3
Lars Karlsson et al.
Scientific reports, 9(1), 12320-12320 (2019-08-25)
Aerobic exercise prevents age-dependent decline in cognition and hippocampal neurogenesis. The transcription factor peroxisome proliferator-activated receptor gamma co-activator 1-alpha (PGC-1α) mediates many of the exercise-induced benefits in skeletal muscle, including the release of factors into the circulation with neurotrophic effects.
相关内容
Myokine analysis with multiplex immunoassays, such as the MILLIPLEX® Human Myokine Panel, allow researchers to simultaneously measure multiple muscle-secreted factors, providing more insights into related diseases.
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