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安全信息

MMMP3MAG-79K

Millipore

MILLIPLEX®小鼠MMP磁珠组套 - 免疫学多重检测试剂盒

MMP Bead-Based Multiplex Assays using the Luminex technology enables the simultaneous analysis of multiple MMP biomarkers in mouse cell culture samples.

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UNSPSC代码:
12161503
eCl@ss:
32161000
NACRES:
NA.84

质量水平

200

种属反应性

mouse

制造商/商品名称

Milliplex®

assay range

standard curve range: 12-50,000 pg/mL
(MMP-8)
standard curve range: 12-50,000 pg/mL
(proMMP-9)
standard curve range: 2-10,000 pg/mL
(MMP-3)
standard curve range: 49-200,000 pg/mL
(MMP-2)
standard curve range: 5-20,000 pg/mL
(MMP-12)

技术

multiplexing: suitable

检测方法

fluorometric (Luminex xMAP)

运输

wet ice

相关类别

一般描述

MMPs（基质金属蛋白酶）是负责细胞外基质(ECM)分解的锌蛋白酶家族，在正常的生理过程中起关键作用，例如胚胎发育和组织形态发生、组织和骨骼重塑、伤口愈合和血管生成。这些过程依赖于MMPs在细胞表面受体的裂解、凋亡配体的释放、细胞增殖和分化以及趋化因子活性调节中的作用。在结构上相似，MMP被合成并分泌为需要蛋白水解切割才能激活的无活性原酶。该过程可以由丝氨酸蛋白酶或其他MMP介导。MMP表达的增加是对多种刺激（包括粘附分子、生长因子、细胞因子和激素）的响应而发生的。MMP活性的调节主要由TIMP（金属蛋白酶的组织抑制剂）控制。因此，MMP/TIMP平衡的破坏可导致自身免疫性疾病、关节炎、心血管疾病以及肿瘤的生长和转移。

MILLIPLEX®小鼠MMP珠组套3，MMMP3MAG-79K是一种5重试剂盒，用于同时定量组织培养样品中的以下任何或所有分析物：MMP-2、MMP-3、MMP-8、proMMP-9和MMP-12。

组套类型：细胞因子/趋化因子

特异性

本组套中抗体与任何其他分析物之间的交叉反应性不可检出或可忽略不计。

应用

  • 分析物：MMP-2、MMP-3、MMP-8、proMMP-9、MMP-12
  • 建议样品类型：细胞/组织培养上清液或提取物
  • 研究类别：炎症&免疫学

特点和优势

通过在此组套中选择可用的分析物来设计多重试剂盒。

储存及稳定性

试剂盒组件的建议储存温度为2 - 8°C。

其他说明

灵敏度：单个分析物的灵敏度见方案

法律信息

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

除非我们的目录或产品随附的其他公司文件中另有说明，否则我们的产品预期仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或对人类或动物的任何类型的消费或应用。

象形图

Skull and crossbonesEnvironment
GHS06,GHS09

警示用语：

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Sens. 1

WGK

WGK 3

法规信息

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