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Merck
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MCD8MAG-48K

MILLIPLEX®小鼠CD8+ T细胞磁珠组套 - 多重检测试剂盒

Configurable Mouse CD8+ T Cell 15-Plex Panel

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关于此项目

UNSPSC Code:
12161503
NACRES:
NA.47
eCl@ss:
32161000
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产品名称

MILLIPLEX®小鼠CD8+ T细胞磁珠组套 - 多重检测试剂盒, Configurable Mouse CD8+ T Cell 15-Plex Panel

species reactivity

mouse

manufacturer/tradename

Milliplex®

Quality Level

packaging

1 ea of

assay range

standard curve range: 12.2-50,000 pg/mL
(IL-6)

standard curve range: 2.4-10,000 pg/mL
(Granzyme B, IL-4, TNFα)

standard curve range: 24.4-100,000 pg/mL
(sFas, sFas Ligand, GM-CSF)

standard curve range: 3.7-15,000 pg/mL
(IL-5)

standard curve range: 4.9-20,000 pg/mL
(sCD137 IFNγ, IL-2, MIP-1ß, RANTES)

standard curve range: 48.8-200,000 pg/mL
(IL-13)

standard curve range: 6.1-25,000 pg/mL
(IL-10)

technique(s)

multiplexing: suitable

input

cell culture supernatant(s)

detection method

fluorometric (Luminex xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 15 analytes in mouse serum, plasma, and cell culture supernatants.

Analytes included: sCD137, sFas, sFAS ligand, GM-CSF, Granzyme B, IFNγ, IL-2, IL-4, IL-5, IL-6, IL-10, IL-13, MIP-1β, RANTES, TNF-α

Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.

Disclaimer

For research use only. Not for use in diagnostic procedures.

Label License/Sticker for Assay Product:

By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

Features and Benefits

Save Time, Samples, and Budget: With just 25 µL of sample, you can measure up to 15 analytes—minimizing animal use and maximizing data output. This efficiency translates to faster results and lower costs per data point.

Unlock Deeper Insights into Immune Function: This panel is designed to decode the complexity of CD8+ T cell responses, giving researchers a powerful lens into cytotoxic activity, immune regulation, and inflammation—all in one assay

Trusted Performance with Proven Reproducibility: Built on the Luminex® xMAP® platform, this panel delivers high sensitivity, low variability, and robust reproducibility, ensuring confidence in every data set.

General description

CD8+ T cells (also known as cytotoxic T cells, cytolytic T cells and killer T cells) belong to a sub-group of T cells capable of inducing the death of infected somatic or tumor cells. T cells that bind weakly to Major Histocompatibility Complex (MHC) self-antigens are positively selected into single-positive CD4+ or CD8+ T cells in the thymus. Those CD8+ T cells that survive and mature after activation become cytotoxic cells, expressing T-cell receptors (TCRs) capable of recognizing specific antigenic peptides bound to Class I MHC molecules and the glycoprotein CD8. Affinity between the CD8 protein and the MHC molecule helps to keep the cytotoxic T cell and target closely bound during antigen specific activation. Once activated, CD8+ T cells are generally classified as having a predefined cytotoxic role within the immune system and undergo IL-2 induced clonal expansion, which increases the number of cells specific for the target antigen. The CD8+ T cells then travel throughout the body in search of antigen-positive somatic/tumor cells.

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Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

存储类别

10 - Combustible liquids

wgk

WGK 3

法规信息

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Virus-induced CD8+ T cells accelerate the onset of experimental autoimmune encephalomyelitis: implications for how viral infections might trigger multiple sclerosis exacerbations.
Rainey-Barger, EK; Blakely, PK; Huber, AK; Segal, BM; Irani, DN
Journal of Neuroimmunology null
Shimin Wang et al.
Scientific reports, 6, 24249-24249 (2016-04-15)
Regulatory T cells (Tregs) expand in peripheral lymphoid organs and can produce immunosuppressive cytokines to support tumor growth. IL-10 abrogation efficiently induces Treg formation but dampens tumoral neuropilin-1 (Nrp-1) Treg signaling, which simultaneously augments Th1 and Th17 immunity. These effects
Delphine Le Guennec et al.
Cancers, 14(1) (2022-01-12)
Our goal was to evaluate the effect of spontaneous physical activity on tumour immunity during aging. Elderly (n = 10/group, 33 weeks) ovariectomized C57BL/6J mice fed a hyperlipidic diet were housed in standard (SE) or enriched (EE) environments. After 4

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