物料
flat bottom wells
polycarbonate membrane
polystyrene
质量水平
描述
Clear, Sterile, 5.0 µm pore size, Polycarbonate (PC) membrane, 10 plates
无菌性
sterile
产品线
MultiScreen®
特点
lid
制造商/商品名称
MultiScreen®
参数
50-250 μL sample volume (per well)
技术
DNA purification: suitable
过滤面积
0.28 cm2
板尺寸
96 wells
孔最大体积
350 μL
工作体积
50-75 μL
孔径
5.0 μm pore size
吸附类型
Tissue Culture (TC)-treated surface
运输
ambient
相关类别
一般描述
MultiScreen®-MIC (Migration, Invasion, Chemotaxis)平板是一种96孔的一次性装置，用于在药物发现中筛选蛋白库和化合物先导物的功能检测。它旨在使用单个设备支持高通量细胞功能检测，如悬浮和/或贴壁细胞系的迁移、侵袭和趋化性。该平板可用于执行和量化细胞迁移或入侵跨涂层或未涂层膜，以响应浓度梯度。MultiScreen-MIC平板具有多种孔径，可用于多种细胞系的MIC测定，并且仅用于单次使用。
应用
MultiScreen® 96孔迁移侵袭和趋化滤板已用于transwell/细胞迁移检测，使用：
- 经白细胞介素(IL)-4-和IL-12处理的T细胞
- THP-1（人急性单核细胞白血病细胞系）
- 体外激活、纯化和维持半乳糖凝集素-3缺陷(gal3)-/-和gal3+/+分化4 (CD4)+ OTII T细胞簇
法律信息
MULTISCREEN is a registered trademark of Merck KGaA, Darmstadt, Germany
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Huan-Yuan Chen et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(34), 14496-14501 (2009-08-27)
We have investigated the function of endogenous galectin-3 in T cells. Galectin-3-deficient (gal3(-/-)) CD4(+) T cells secreted more IFN-gamma and IL-4 than gal3(+/+)CD4(+) T cells after T-cell receptor (TCR) engagement. Galectin-3 was recruited to the cytoplasmic side of the immunological
Jeremy Green et al.
Journal of medicinal chemistry, 58(12), 5028-5037 (2015-06-04)
The Rho kinases (ROCK1 and ROCK2) are highly homologous serine/threonine kinases that act on substrates associated with cellular motility, morphology, and contraction and are of therapeutic interest in diseases associated with cellular migration and contraction, such as hypertension, glaucoma, and
Tilo Biedermann et al.
Journal of immunology (Baltimore, Md. : 1950), 177(6), 3763-3770 (2006-09-05)
Distinct pattern of homing receptors determines the tissue preference for T cells to exert their effector functions. This homing competence is mostly determined early during T cell activation of naive T cells. In contrast, mechanisms governing the acquisition of particular
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